CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009096
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium-transporting ATPase type 2C member 1 
Protein Synonyms/Alias
 ATPase 2C1; Secretory pathway Ca(2+)-transporting ATPase 
Gene Name
 ATP2C1 
Gene Synonyms/Alias
 SPCA 
Created Date
 July 27, 2013 
Organism
 Bos taurus (Bovine) 
NCBI Taxa ID
 9913 
Lysine Modification
Position
Peptide
Type
References
483LQQDYIRKAEYPFSSubiquitination[1]
668KIIKSLQKNGSVVAMubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. 
Sequence Annotation
 ACT_SITE 384 384 4-aspartylphosphate intermediate (By
 METAL 337 337 Calcium 2; via carbonyl oxygen (By
 METAL 338 338 Calcium 2; via carbonyl oxygen (By
 METAL 340 340 Calcium 2; via carbonyl oxygen (By
 METAL 342 342 Calcium 2 (By similarity).
 METAL 678 678 Magnesium (By similarity).
 METAL 682 682 Magnesium (By similarity).
 METAL 772 772 Calcium 2 (By similarity).
 METAL 776 776 Calcium 2 (By similarity).  
Keyword
 ATP-binding; Calcium; Calcium transport; Complete proteome; Golgi apparatus; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 953 AA 
Protein Sequence
MDNLLPQSRF SYFKKYPIHA IRKYLSMLRN QKEEEQVARF QKIPNAENET MIPVLTSKKA 60
SELPVSEVAS ILQADLQNGL NKCEVSHRRA FHGWNEFDIS EDEPLWKKYI SQFKNPLIML 120
LLASAVISVL MHQFDDAVSI TVAILIVVTV AFVQEYRSEK SLEELSKLMP PECHCVREGK 180
LEHTLARDLV PGDTVCLSVG DRVPADLRLF EAVDLSVDES SLTGETTPCS KVTAPQPAAT 240
NGDLASRSNI AFMGTLVRCG KAKGIVIGTG ENSEFGEVFK MMQAEEAPKT PLQKSMDLLG 300
KQLSFYSFGI IGIIMLVGWL LGKDILEMFT ISVSLAVAAI PEGLPIVVTV TLALGVMRMV 360
KKRAIVKKLP IVETLGCCNV ICSDKTGTLT KNEMTVTHIF TSDGLRAEVT GVGYNPFGEV 420
IVDGDVVHGF YNPSVSRIVE AGCVCNDAVI RNNTLMGKPT EGALIALAMK MGLDGLQQDY 480
IRKAEYPFSS EQKWMAVKCV HRTQQDRPEI CFMKGAYEQV IKYCTTYHSK GQTLTLTQQQ 540
RDLYQQEKAQ MGSAGLRVLA LASGPELGQL TFLGLVGIID PPRTGVKEAV TTLIASGVSI 600
KMITGDSQET AVAIASRLGL YSKTSQSVSG EEIDAMDVQQ LSQIVPKVAV FYRASPRHKM 660
KIIKSLQKNG SVVAMTGDGV NDAVALKAAD IGVAMGQTGT DVCKEAADMI LVDDDFQTIM 720
SAIEEGKGIY NNIKNFVRFQ LSTSIAALTL ISLATLMNFP NPLNAMQILW INIIMDGPPA 780
QSLGVEPVDK DVIRKPPRNW KDSILTKNLI LKILVSSIII VCGTLFVFWR ELRDNVITPR 840
DTTMTFTCFV FFDMFNALSS RSQTKSVFEI GLCSNKMFCY AVLGSIMGQL LVIYFPPLQK 900
VFQTESLSIL DLLFLLGLTS SVCIVAEIIK KVERSREKIQ KPVSSTSSSF LEV 953 
Gene Ontology
 GO:0000139; C:Golgi membrane; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0005509; F:calcium ion binding; ISS:UniProtKB.
 GO:0005388; F:calcium-transporting ATPase activity; ISS:UniProtKB.
 GO:0030145; F:manganese ion binding; ISS:UniProtKB.
 GO:0015410; F:manganese-transporting ATPase activity; ISS:UniProtKB.
 GO:0004871; F:signal transducer activity; ISS:UniProtKB.
 GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.
 GO:0016339; P:calcium-dependent cell-cell adhesion; ISS:UniProtKB.
 GO:0030026; P:cellular manganese ion homeostasis; ISS:UniProtKB.
 GO:0008544; P:epidermis development; ISS:UniProtKB.
 GO:0032468; P:Golgi calcium ion homeostasis; ISS:UniProtKB.
 GO:0032472; P:Golgi calcium ion transport; ISS:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB. 
Interpro
 IPR006413; ATPase_P-typ_Ca-transp_PMR1.
 IPR006068; ATPase_P-typ_cation-transptr_C.
 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR023298; ATPase_P-typ_TM_dom.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF00689; Cation_ATPase_C
 PF00690; Cation_ATPase_N
 PF00122; E1-E2_ATPase
 PF00702; Hydrolase 
SMART
 SM00831; Cation_ATPase_N 
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.
 PR00120; HATPASE.