UniProt Accession

 GP126_HUMAN; Q86SQ4; Q5TGN7; Q6DHZ4; Q6F3F5; Q6F3F6; Q6F3F7; Q6F3F8; Q6MZU7; Q8IXA4; Q8NC14; Q96JW0 

Genbank Protein ID

 AF216967; AB183546; AB183547; AB183548; AB183549; BX640971; BX640873; AL033377; AL360007; BC075798; AK027843; AK075087; AY181244; AY426673 

Genbank Nucleotide ID

 AAO13250.1; BAD27571.1; BAD27572.1; BAD27573.1; BAD27574.1; CAE45986.1; CAE45930.1; CAI20053.1; AAH75798.1; BAB55406.1; BAC11393.1; AAO27356.1; AAR88427.1 

Protein Name

 G-protein coupled receptor 126 

Protein Synonyms/Alias

 Developmentally regulated G-protein-coupled receptor; Vascular inducible G protein-coupled receptor 

Gene Name

 GPR126 

Gene Synonyms/Alias

 DREG; VIGR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
1176	NSTYLTSKSKSSSTT	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels (By similarity). 

Sequence Annotation

 DOMAIN 41 149 CUB.
 DOMAIN 150 355 Pentaxin.
 DOMAIN 800 852 GPS.
 MOD_RES 1165 1165 Phosphoserine.
 CARBOHYD 121 121 N-linked (GlcNAc...) (Potential).
 CARBOHYD 143 143 N-linked (GlcNAc...).
 CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).
 CARBOHYD 258 258 N-linked (GlcNAc...) (Potential).
 CARBOHYD 314 314 N-linked (GlcNAc...) (Potential).
 CARBOHYD 324 324 N-linked (GlcNAc...).
 CARBOHYD 353 353 N-linked (GlcNAc...) (Potential).
 CARBOHYD 438 438 N-linked (GlcNAc...).
 CARBOHYD 445 445 N-linked (GlcNAc...).
 CARBOHYD 452 452 N-linked (GlcNAc...) (Potential).
 CARBOHYD 485 485 N-linked (GlcNAc...) (Potential).
 CARBOHYD 488 488 N-linked (GlcNAc...) (Potential).
 CARBOHYD 505 505 N-linked (GlcNAc...) (Potential).
 CARBOHYD 563 563 N-linked (GlcNAc...) (Potential).
 CARBOHYD 593 593 N-linked (GlcNAc...) (Potential).
 CARBOHYD 600 600 N-linked (GlcNAc...) (Potential).
 CARBOHYD 605 605 N-linked (GlcNAc...) (Potential).
 CARBOHYD 667 667 N-linked (GlcNAc...) (Potential).
 CARBOHYD 673 673 N-linked (GlcNAc...) (Potential).
 CARBOHYD 695 695 N-linked (GlcNAc...) (Potential).
 CARBOHYD 704 704 N-linked (GlcNAc...) (Potential).
 CARBOHYD 750 750 N-linked (GlcNAc...) (Potential).
 CARBOHYD 776 776 N-linked (GlcNAc...) (Potential).
 CARBOHYD 811 811 N-linked (GlcNAc...) (Potential).
 CARBOHYD 818 818 N-linked (GlcNAc...) (Potential).
 DISULFID 41 67 By similarity.
 DISULFID 94 111 By similarity.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1221 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; TAS:GDB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004930; F:G-protein coupled receptor activity; TAS:GDB.
 GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro. 

Interpro

 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR000859; CUB_dom.
 IPR017981; GPCR_2-like.
 IPR000832; GPCR_2_secretin-like.
 IPR017983; GPCR_2_secretin-like_CS.
 IPR000203; GPS_dom.
 IPR001759; Pentaxin. 

Pfam

 PF00002; 7tm_2
 PF00431; CUB
 PF01825; GPS
 PF00354; Pentaxin 

SMART

 SM00042; CUB
 SM00303; GPS 

PROSITE

 PS01180; CUB
 PS00649; G_PROTEIN_RECEP_F2_1
 PS00650; G_PROTEIN_RECEP_F2_2
 PS50227; G_PROTEIN_RECEP_F2_3
 PS50261; G_PROTEIN_RECEP_F2_4
 PS50221; GPS 

PRINTS

 PR00249; GPCRSECRETIN.