UniProt Accession

 MX1_HUMAN; P20591; B2RDA5; B3KU10; C9IYV7; C9J8D6; C9JN19; C9JN88; C9JUL1; C9JZS6; D3DSI8; Q86YP5; Q96CI3 

Genbank Protein ID

 M30817; M33882; AF135187; AK096355; AK315465; AL163285; AL773577; AL773578; AP001610; CH471079; CH471079; CH471079; CH471079; CH471079; BC014222; BC032602; AY186254 

Genbank Nucleotide ID

 AAA36337.1; AAA36458.1; AAD43063.1; BAG53272.1; BAG37852.1; CAB90556.1; EAX09600.1; EAX09601.1; EAX09602.1; EAX09603.1; EAX09604.1; AAH14222.2; AAH32602.1; AAO31807.1 

Protein Name

 Interferon-induced GTP-binding protein Mx1 

Protein Synonyms/Alias

 Interferon-induced protein p78; IFI-78K; Interferon-regulated resistance GTP-binding protein MxA; Myxoma resistance protein 1; Myxovirus resistance protein 1; Interferon-induced GTP-binding protein Mx1, N-terminally processed 

Gene Name

 MX1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
31	GDATVAQKNPGSVAE	ubiquitination	[1]
83	IGDQSSGKSSVLEAL	ubiquitination	[1]
110	TRCPLVLKLKKLVNE	ubiquitination	[1]
113	PLVLKLKKLVNEDKW	ubiquitination	[1]
119	KKLVNEDKWRGKVSY	ubiquitination	[1]
197	QPADIGYKIKTLIKK	ubiquitination	[1]
273	NLVFHLKKGYMIVKC	ubiquitination	[1]
317	RDLLEEGKATVPCLA	ubiquitination	[1]
432	GHKILSRKIQKFENQ	ubiquitination	[1]
435	ILSRKIQKFENQYRG	ubiquitination	[1]
459	RTFETIVKQQIKALE	ubiquitination	[1]
490	AFTDVSIKNFEEFFN	ubiquitination	[1]
505	LHRTAKSKIEDIRAE	ubiquitination	[1]
631	DTYSWLLKERSDTSD	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs. 

Sequence Annotation

 DOMAIN 574 662 GED.
 NP_BIND 77 84 GTP (Potential).
 NP_BIND 178 182 GTP (Potential).
 NP_BIND 247 250 GTP (Potential).
 REGION 69 340 GTPase domain (Globular).
 REGION 341 366 Bundle signaling element (BSE).
 REGION 366 533 Middle domain.
 REGION 367 632 Stalk.
 REGION 554 557 Critical for lipid-binding.
 MOD_RES 1 1 N-acetylmethionine; in Interferon-induced  

Keyword

 3D-structure; Acetylation; Alternative splicing; Antiviral defense; Complete proteome; Cytoplasm; Direct protein sequencing; Endoplasmic reticulum; GTP-binding; Immunity; Innate immunity; Membrane; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 662 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005525; F:GTP binding; TAS:ProtInc.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0006917; P:induction of apoptosis; TAS:ProtInc.
 GO:0045071; P:negative regulation of viral genome replication; IDA:UniProtKB.
 GO:0009615; P:response to virus; IMP:UniProtKB.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR022812; Dynamin.
 IPR000375; Dynamin_central.
 IPR001401; Dynamin_GTPase.
 IPR019762; Dynamin_GTPase_CS.
 IPR003130; GED.
 IPR020850; GTPase_effector_domain_GED.
 IPR015577; Interferon-induced_Mx.
 IPR027417; P-loop_NTPase. 

Pfam

 PF01031; Dynamin_M
 PF00350; Dynamin_N
 PF02212; GED 

SMART

 SM00053; DYNc
 SM00302; GED 

PROSITE

 PS00410; DYNAMIN
 PS51388; GED 

PRINTS

 PR00195; DYNAMIN.