UniProt Accession

 KCNK5_HUMAN; O95279; B5TJL2; Q5VV76 

Genbank Protein ID

 AF084830; EU978936; AL451185; CH471081; BC060793; BC069573 

Genbank Nucleotide ID

 AAC79458.1; ACH86095.1; CAH70466.1; EAX03979.1; AAH60793.1; AAH69573.1 

Protein Name

 Potassium channel subfamily K member 5 

Protein Synonyms/Alias

 Acid-sensitive potassium channel protein TASK-2; TWIK-related acid-sensitive K(+) channel 2 

Gene Name

 KCNK5 

Gene Synonyms/Alias

 TASK2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
150	RLGQFLTKRGVSLRK	ubiquitination	[1, 2]
286	VKGSTASKDVNIFSF	ubiquitination	[2, 3]
296	NIFSFLSKKEETYND	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations. 

Sequence Annotation

 MOD_RES 371 371 Phosphoserine.
 CARBOHYD 77 77 N-linked (GlcNAc...) (Potential).
 DISULFID 51 51 Interchain.  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; Polymorphism; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 499 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005267; F:potassium channel activity; TAS:ProtInc.
 GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
 GO:0007588; P:excretion; TAS:ProtInc. 

Interpro

 IPR003280; 2pore_dom_K_chnl.
 IPR003092; 2pore_dom_K_chnl_TASK.
 IPR013099; Ion_trans_2. 

Pfam

 PF07885; Ion_trans_2 

SMART

  

PROSITE

  

PRINTS

 PR01333; 2POREKCHANEL.
 PR01095; TASKCHANNEL.