UniProt Accession

 BECN1_YEAST; Q02948; D6W3P7 

Genbank Protein ID

 AB011072; U43503; BK006949 

Genbank Nucleotide ID

 BAA32104.1; AAB68242.1; DAA11313.1 

Protein Name

 Vacuolar protein sorting-associated protein 30 

Protein Synonyms/Alias

 Autophagy-related protein 6 

Gene Name

 VPS30 

Gene Synonyms/Alias

 APG6; ATG6; VPT30; YPL120W; LPH7 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
552	PTVNYNDKTISGN**	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy- specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3- kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Plays also a role in regulation of filamentous growth. 

Sequence Annotation

 REGION 320 539 BARA.
 MOD_RES 142 142 Phosphothreonine.  

Keyword

 3D-structure; Autophagy; Coiled coil; Complete proteome; Endosome; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport; Vacuole. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 557 AA 

Protein Sequence

Gene Ontology

 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0019898; C:extrinsic to membrane; IDA:SGD.
 GO:0034271; C:phosphatidylinositol 3-kinase complex I; IDA:SGD.
 GO:0034272; C:phosphatidylinositol 3-kinase complex II; IDA:SGD.
 GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
 GO:0032258; P:CVT pathway; IMP:SGD.
 GO:0045324; P:late endosome to vacuole transport; IMP:SGD.
 GO:0016236; P:macroautophagy; IMP:SGD.
 GO:0030242; P:peroxisome degradation; IMP:SGD.
 GO:0006661; P:phosphatidylinositol biosynthetic process; IMP:SGD.
 GO:0034727; P:piecemeal microautophagy of nucleus; IMP:SGD.
 GO:0042147; P:retrograde transport, endosome to Golgi; IMP:SGD. 

Interpro

 IPR007243; Beclin_fam. 

Pfam

 PF04111; APG6 

SMART

  

PROSITE

  

PRINTS