CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019635
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Structural maintenance of chromosomes protein 6 
Protein Synonyms/Alias
 SMC protein 6; SMC-6; hSMC6 
Gene Name
 SMC6 
Gene Synonyms/Alias
 SMC6L1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
256YSYIMETKERTKEQIubiquitination[1]
294IAGLSTMKTNLESLKubiquitination[1]
684SSENTRPKFLSRDVDubiquitination[1]
812KYDAIKFKINQLSELubiquitination[1]
888PERIEVEKSASILDKubiquitination[1]
943RTLKKFIKLLGEIMEubiquitination[1]
954EIMEHRFKTYQQFRRubiquitination[1]
1086MSSLPSSKLIRILRMubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. 
Sequence Annotation
 NP_BIND 76 83 ATP (Potential).
 REGION 452 659 Flexible hinge.
 MOD_RES 669 669 Phosphoserine.  
Keyword
 Alternative splicing; ATP-binding; Chromosome; Coiled coil; Complete proteome; DNA damage; DNA recombination; DNA repair; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Telomere; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1091 AA 
Protein Sequence
MAKRKEENFS SPKNAKRPRQ EELEDFDKDG DEDECKGTTL TAAEVGIIES IHLKNFMCHS 60
MLGPFKFGSN VNFVVGNNGS WSAVVRSRLN ATSASQVQAI LLFQPCGKSA VLTALIVGLG 120
GRAVATNRGS SLKGFVKDGQ NSADISITLR NRGDDAFKAS VYGNSILIQQ HISIDGSRSY 180
KLKSATGSVV STRKEELIAI LDHFNIQVDN PVSVLTQEMS KQFLQSKNEG DKYKFFMKAT 240
QLEQMKEDYS YIMETKERTK EQIHQGEERL TELKRQCVEK EERFQSIAGL STMKTNLESL 300
KHEMAWAVVN EIEKQLNAIR DNIKIGEDRA ARLDRKMEEQ QVRLNEAEQK YKDIQDKLEK 360
ISEETNARAP ECMALKADVV AKKRAYNEAE VLYNRSLNEY KALKKDDEQL CKRIEELKKS 420
TDQSLEPERL ERQKKISWLK ERVKAFQNQE NSVNQEIEQF QQAIEKDKEE HGKIKREELD 480
VKHALSYNQR QLKELKDSKT DRLKRFGPNV PALLEAIDDA YRQGHFTYKP VGPLGACIHL 540
RDPELALAIE SCLKGLLQAY CCHNHADERV LQALMKRFYL PGTSRPPIIV SEFRNEIYDV 600
RHRAAYHPDF PTVLTALEID NAVVANSLID MRGIETVLLI KNNSVARAVM QSQKPPKNCR 660
EAFTADGDQV FAGRYYSSEN TRPKFLSRDV DSEISDLENE VENKTAQILN LQQHLSALEK 720
DIKHNEELLK RCQLHYKELK MKIRKNISEI RELENIEEHQ SVDIATLEDE AQENKSKMKM 780
VEEHMEQQKE NMEHLKSLKI EAENKYDAIK FKINQLSELA DPLKDELNLA DSEVDNQKRG 840
KRHYEEKQKE HLDTLNKKKR ELDMKEKELE EKMSQARQIC PERIEVEKSA SILDKEINRL 900
RQKIQAEHAS HGDREEIMRQ YQEARETYLD LDSKVRTLKK FIKLLGEIME HRFKTYQQFR 960
RCLTLRCKLY FDNLLSQRAY CGKMNFDHKN ETLSISVQPG EGNKAAFNDM RALSGGERSF 1020
STVCFILSLW SIAESPFRCL DEFDVYMDMV NRRIAMDLIL KMADSQRFRQ FILLTPQSMS 1080
SLPSSKLIRI LRMSDPERGQ TTLPFRPVTQ EEDDDQR 1117 
Gene Ontology
 GO:0000781; C:chromosome, telomeric region; IDA:UniProtKB.
 GO:0016605; C:PML body; IDA:UniProtKB.
 GO:0030915; C:Smc5-Smc6 complex; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0090398; P:cellular senescence; IMP:UniProtKB.
 GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
 GO:0000722; P:telomere maintenance via recombination; IMP:UniProtKB. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR003395; RecF/RecN/SMC.
 IPR027132; SMC6. 
Pfam
 PF02463; SMC_N 
SMART
  
PROSITE
  
PRINTS