UniProt Accession

 C9J3G2_HUMAN; C9J3G2 

Genbank Protein ID

 AC016745; AL078621 

Genbank Nucleotide ID

  

Protein Name

 COBW domain-containing protein 2 

Protein Synonyms/Alias

  

Gene Name

 CBWD2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
126	AIENLMQKKGKFDYI	ubiquitination	[1]
176	VDSKYGLKHLAEEKP	ubiquitination	[1, 2, 3]
182	LKHLAEEKPDGLINE	ubiquitination	[3]
204	ADAILINKTDLVPEE	ubiquitination	[1, 2, 3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 376 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR011629; Cbl_biosynth_CobW-like_C.
 IPR003495; CobW/HypB/UreG_dom.
 IPR027417; P-loop_NTPase. 

Pfam

 PF02492; cobW
 PF07683; CobW_C 

SMART

 SM00833; CobW_C 

PROSITE

  

PRINTS