UniProt Accession

 DIRA2_HUMAN; Q96HU8; B3KVM2 

Genbank Protein ID

 AB076889; AK122986; AL353619; CH471089; BC008065 

Genbank Nucleotide ID

 BAC01116.1; BAG53834.1; CAI15748.1; EAW62780.1; AAH08065.1 

Protein Name

 GTP-binding protein Di-Ras2 

Protein Synonyms/Alias

 Distinct subgroup of the Ras family member 2 

Gene Name

 DIRAS2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
29	SLVLRFVKGTFRESY	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Displays low GTPase activity and exist predominantly in the GTP-bound form. 

Sequence Annotation

 NP_BIND 14 21 GTP.
 NP_BIND 33 39 GTP.
 NP_BIND 61 65 GTP.
 NP_BIND 121 124 GTP.
 MOTIF 36 44 Effector region (Potential).
 MOD_RES 196 196 Cysteine methyl ester (Potential).
 LIPID 196 196 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 199 AA 

Protein Sequence

Gene Ontology

 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.