CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022462
UniProt Accession
Genbank Protein ID
 AF176832; AF283343; AF283342; AF283327; AF283328; AF283329; AF283330; AF283331; AF283332; AF283333; AF283334; AF283335; AF283336; AF283337; AF283338; AF283339; AF283340; AF283341; AF283374; AF283344; AF283345; AF283346; AF283347; AF283348; AF283349; AF283350; AF283351; AF283352; AF283353; AF283354; AF283355; AF283356; AF283357; AF283358; AF283359; AF283360; AF283361; AF283362; AF283363; AF283364; AF283366; AF283367; AF283368; AF283369; AF283370; AF283371; AF283372; AF283373; AF283408; AF283376; AF283377; AF283378; AF283379; AF283380; AF283381; AF283382; AF283383; AF283384; AF283385; AF283386; AF283387; AF283388; AF283389; AF283390; AF283391; AF283392; AF283393; AF283394; AF283395; AF283396; AF283397; AF283398; AF283399; AF283400; AF283401; AF283402; AF283403; AF283404; AF283405; AF283406; AF283407 
Genbank Nucleotide ID
 AAF70379.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38107.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38108.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1; AAL38109.1 
Protein Name
 Low-density lipoprotein receptor-related protein 1B 
Protein Synonyms/Alias
 LRP-1B; Low-density lipoprotein receptor-related protein-deleted in tumor; LRP-DIT 
Gene Name
 LRP1B 
Gene Synonyms/Alias
 LRPDIT 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
678DSVGRIEKAWMDGFNubiquitination[1]
693RQIFVTSKMLWPNGLubiquitination[1]
2113GSVRRGHKNDATETIubiquitination[1]
4468VIGLVLCKRKRRTKTubiquitination[1]
4588ERKELLPKKIEIGIRubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. 
Sequence Annotation
 DOMAIN 31 70 LDL-receptor class A 1.
 DOMAIN 76 114 LDL-receptor class A 2.
 DOMAIN 116 154 EGF-like 1.
 DOMAIN 155 194 EGF-like 2; calcium-binding (Potential).
 REPEAT 245 294 LDL-receptor class B 1.
 REPEAT 295 337 LDL-receptor class B 2.
 REPEAT 338 381 LDL-receptor class B 3.
 REPEAT 382 425 LDL-receptor class B 4.
 REPEAT 568 610 LDL-receptor class B 5.
 REPEAT 611 656 LDL-receptor class B 6.
 REPEAT 657 706 LDL-receptor class B 7.
 REPEAT 707 750 LDL-receptor class B 8.
 DOMAIN 794 834 EGF-like 3.
 DOMAIN 844 882 LDL-receptor class A 3.
 DOMAIN 885 923 LDL-receptor class A 4.
 DOMAIN 926 963 LDL-receptor class A 5.
 DOMAIN 966 1003 LDL-receptor class A 6.
 DOMAIN 1005 1043 LDL-receptor class A 7.
 DOMAIN 1052 1089 LDL-receptor class A 8.
 DOMAIN 1094 1132 LDL-receptor class A 9.
 DOMAIN 1135 1174 LDL-receptor class A 10.
 REPEAT 1300 1346 LDL-receptor class B 9.
 REPEAT 1347 1389 LDL-receptor class B 10.
 REPEAT 1390 1436 LDL-receptor class B 11.
 REPEAT 1437 1480 LDL-receptor class B 12.
 REPEAT 1481 1522 LDL-receptor class B 13.
 REPEAT 1618 1660 LDL-receptor class B 14.
 REPEAT 1661 1704 LDL-receptor class B 15.
 REPEAT 1705 1744 LDL-receptor class B 16.
 REPEAT 1745 1787 LDL-receptor class B 17.
 REPEAT 1788 1830 LDL-receptor class B 18.
 DOMAIN 1834 1875 EGF-like 4.
 REPEAT 1922 1964 LDL-receptor class B 19.
 REPEAT 1965 2007 LDL-receptor class B 20.
 REPEAT 2008 2051 LDL-receptor class B 21.
 REPEAT 2052 2095 LDL-receptor class B 22.
 DOMAIN 2143 2183 EGF-like 5.
 REPEAT 2239 2280 LDL-receptor class B 23.
 REPEAT 2281 2329 LDL-receptor class B 24.
 REPEAT 2330 2374 LDL-receptor class B 25.
 REPEAT 2375 2416 LDL-receptor class B 26.
 REPEAT 2417 2459 LDL-receptor class B 27.
 DOMAIN 2509 2548 LDL-receptor class A 11.
 DOMAIN 2551 2587 LDL-receptor class A 12.
 DOMAIN 2590 2626 LDL-receptor class A 13.
 DOMAIN 2629 2675 LDL-receptor class A 14.
 DOMAIN 2681 2717 LDL-receptor class A 15.
 DOMAIN 2719 2757 LDL-receptor class A 16.
 DOMAIN 2760 2800 LDL-receptor class A 17.
 DOMAIN 2804 2841 LDL-receptor class A 18.
 DOMAIN 2844 2885 LDL-receptor class A 19.
 DOMAIN 2890 2926 LDL-receptor class A 20.
 DOMAIN 2926 2967 EGF-like 6.
 DOMAIN 2968 3008 EGF-like 7.
 REPEAT 3055 3098 LDL-receptor class B 28.
 REPEAT 3099 3141 LDL-receptor class B 29.
 REPEAT 3142 3185 LDL-receptor class B 30.
 REPEAT 3186 3224 LDL-receptor class B 31.
 REPEAT 3225 3268 LDL-receptor class B 32.
 DOMAIN 3316 3353 LDL-receptor class A 21.
 DOMAIN 3356 3392 LDL-receptor class A 22.
 DOMAIN 3395 3432 LDL-receptor class A 23.
 DOMAIN 3435 3472 LDL-receptor class A 24.
 DOMAIN 3475 3511 LDL-receptor class A 25.
 DOMAIN 3514 3550 LDL-receptor class A 26.
 DOMAIN 3552 3588 LDL-receptor class A 27.
 DOMAIN 3593 3629 LDL-receptor class A 28.
 DOMAIN 3631 3668 LDL-receptor class A 29.
 DOMAIN 3673 3711 LDL-receptor class A 30.
 DOMAIN 3714 3752 LDL-receptor class A 31.
 DOMAIN 3761 3797 LDL-receptor class A 32.
 DOMAIN 3801 3843 EGF-like 8.
 DOMAIN 3844 3881 EGF-like 9.
 REPEAT 3933 3980 LDL-receptor class B 33.
 REPEAT 3981 4038 LDL-receptor class B 34.
 REPEAT 4039 4082 LDL-receptor class B 35.
 REPEAT 4083 4127 LDL-receptor class B 36.
 DOMAIN 4213 4246 EGF-like 10.
 DOMAIN 4249 4285 EGF-like 11.
 DOMAIN 4285 4321 EGF-like 12.
 DOMAIN 4321 4357 EGF-like 13.
 DOMAIN 4390 4427 EGF-like 14.
 MOTIF 4492 4495 Endocytosis signal (Potential).
 MOTIF 4559 4562 Endocytosis signal (Potential).
 CARBOHYD 134 134 N-linked (GlcNAc...) (Potential).
 CARBOHYD 190 190 N-linked (GlcNAc...) (Potential).
 CARBOHYD 220 220 N-linked (GlcNAc...) (Potential).
 CARBOHYD 313 313 N-linked (GlcNAc...) (Potential).
 CARBOHYD 360 360 N-linked (GlcNAc...) (Potential).
 CARBOHYD 443 443 N-linked (GlcNAc...) (Potential).
 CARBOHYD 725 725 N-linked (GlcNAc...) (Potential).
 CARBOHYD 758 758 N-linked (GlcNAc...) (Potential).
 CARBOHYD 829 829 N-linked (GlcNAc...) (Potential).
 CARBOHYD 883 883 N-linked (GlcNAc...) (Potential).
 CARBOHYD 919 919 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1041 1041 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1089 1089 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1145 1145 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1209 1209 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1298 1298 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1502 1502 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1549 1549 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1636 1636 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1754 1754 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1816 1816 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1921 1921 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1983 1983 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2105 2105 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2458 2458 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2488 2488 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2507 2507 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2549 2549 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2626 2626 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2647 2647 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2802 2802 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2892 2892 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3034 3034 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3066 3066 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3076 3076 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3164 3164 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3310 3310 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3316 3316 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3682 3682 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3877 3877 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3894 3894 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3906 3906 N-linked (GlcNAc...) (Potential).
 CARBOHYD 4017 4017 N-linked (GlcNAc...) (Potential).
 CARBOHYD 4204 4204 N-linked (GlcNAc...) (Potential).
 CARBOHYD 4381 4381 N-linked (GlcNAc...) (Potential).
 CARBOHYD 4420 4420 N-linked (GlcNAc...) (Potential).
 DISULFID 32 45 By similarity.
 DISULFID 39 58 By similarity.
 DISULFID 52 69 By similarity.
 DISULFID 77 90 By similarity.
 DISULFID 84 103 By similarity.
 DISULFID 97 113 By similarity.
 DISULFID 120 129 By similarity.
 DISULFID 125 138 By similarity.
 DISULFID 140 153 By similarity.
 DISULFID 159 169 By similarity.
 DISULFID 165 178 By similarity.
 DISULFID 180 193 By similarity.
 DISULFID 798 809 By similarity.
 DISULFID 805 818 By similarity.
 DISULFID 820 833 By similarity.
 DISULFID 845 857 By similarity.
 DISULFID 852 870 By similarity.
 DISULFID 864 881 By similarity.
 DISULFID 886 898 By similarity.
 DISULFID 893 911 By similarity.
 DISULFID 905 922 By similarity.
 DISULFID 927 939 By similarity.
 DISULFID 934 952 By similarity.
 DISULFID 946 962 By similarity.
 DISULFID 967 980 By similarity.
 DISULFID 975 993 By similarity.
 DISULFID 987 1002 By similarity.
 DISULFID 1006 1018 By similarity.
 DISULFID 1013 1031 By similarity.
 DISULFID 1025 1042 By similarity.
 DISULFID 1053 1066 By similarity.
 DISULFID 1060 1079 By similarity.
 DISULFID 1073 1088 By similarity.
 DISULFID 1095 1109 By similarity.
 DISULFID 1103 1122 By similarity.
 DISULFID 1116 1131 By similarity.
 DISULFID 1136 1150 By similarity.
 DISULFID 1143 1163 By similarity.
 DISULFID 1157 1173 By similarity.
 DISULFID 1838 1849 By similarity.
 DISULFID 1845 1859 By similarity.
 DISULFID 1861 1874 By similarity.
 DISULFID 2147 2158 By similarity.
 DISULFID 2154 2168 By similarity.
 DISULFID 2170 2182 By similarity.
 DISULFID 2510 2523 By similarity.
 DISULFID 2518 2536 By similarity.
 DISULFID 2530 2547 By similarity.
 DISULFID 2552 2564 By similarity.
 DISULFID 2559 2577 By similarity.
 DISULFID 2571 2586 By similarity.
 DISULFID 2591 2603 By similarity.
 DISULFID 2598 2616 By similarity.
 DISULFID 2610 2625 By similarity.
 DISULFID 2630 2652 By similarity.
 DISULFID 2646 2665 By similarity.
 DISULFID 2659 2674 By similarity.
 DISULFID 2682 2694 By similarity.
 DISULFID 2689 2707 By similarity.
 DISULFID 2701 2716 By similarity.
 DISULFID 2720 2732 By similarity.
 DISULFID 2727 2745 By similarity.
 DISULFID 2739 2756 By similarity.
 DISULFID 2761 2774 By similarity.
 DISULFID 2768 2787 By similarity.
 DISULFID 2781 2799 By similarity.
 DISULFID 2805 2817 By similarity.
 DISULFID 2812 2830 By similarity.
 DISULFID 2824 2840 By similarity.
 DISULFID 2845 2857 By similarity.
 DISULFID 2852 2871 By similarity.
 DISULFID 2865 2884 By similarity.
 DISULFID 2891 2903 By similarity.
 DISULFID 2898 2916 By similarity.
 DISULFID 2910 2925 By similarity.
 DISULFID 2930 2942 By similarity.
 DISULFID 2938 2951 By similarity.
 DISULFID 2953 2966 By similarity.
 DISULFID 2972 2982 By similarity.
 DISULFID 2978 2991 By similarity.
 DISULFID 2993 3007 By similarity.
 DISULFID 3317 3329 By similarity.
 DISULFID 3324 3342 By similarity.
 DISULFID 3336 3352 By similarity.
 DISULFID 3357 3369 By similarity.
 DISULFID 3364 3382 By similarity.
 DISULFID 3376 3391 By similarity.
 DISULFID 3396 3409 By similarity.
 DISULFID 3403 3422 By similarity.
 DISULFID 3416 3431 By similarity.
 DISULFID 3436 3449 By similarity.
 DISULFID 3443 3462 By similarity.
 DISULFID 3456 3471 By similarity.
 DISULFID 3476 3488 By similarity.
 DISULFID 3483 3501 By similarity.
 DISULFID 3495 3510 By similarity.
 DISULFID 3515 3527 By similarity.
 DISULFID 3522 3540 By similarity.
 DISULFID 3534 3549 By similarity.
 DISULFID 3553 3565 By similarity.
 DISULFID 3560 3578 By similarity.
 DISULFID 3572 3587 By similarity.
 DISULFID 3594 3606 By similarity.
 DISULFID 3601 3619 By similarity.
 DISULFID 3613 3628 By similarity.
 DISULFID 3632 3645 By similarity.
 DISULFID 3639 3658 By similarity.
 DISULFID 3652 3667 By similarity.
 DISULFID 3674 3686 By similarity.
 DISULFID 3681 3699 By similarity.
 DISULFID 3693 3710 By similarity.
 DISULFID 3715 3729 By similarity.
 DISULFID 3723 3742 By similarity.
 DISULFID 3736 3751 By similarity.
 DISULFID 3762 3774 By similarity.
 DISULFID 3769 3787 By similarity.
 DISULFID 3781 3796 By similarity.
 DISULFID 3805 3818 By similarity.
 DISULFID 3812 3827 By similarity.
 DISULFID 3829 3842 By similarity.
 DISULFID 3848 3858 By similarity.
 DISULFID 3854 3867 By similarity.
 DISULFID 3869 3880 By similarity.
 DISULFID 4217 4227 By similarity.
 DISULFID 4221 4237 By similarity.
 DISULFID 4253 4263 By similarity.
 DISULFID 4257 4273 By similarity.
 DISULFID 4275 4284 By similarity.
 DISULFID 4289 4299 By similarity.
 DISULFID 4293 4309 By similarity.
 DISULFID 4311 4320 By similarity.
 DISULFID 4325 4335 By similarity.
 DISULFID 4329 4345 By similarity.
 DISULFID 4347 4356 By similarity.
 DISULFID 4394 4404 By similarity.
 DISULFID 4398 4415 By similarity.
 DISULFID 4417 4426 By similarity.  
Keyword
 Calcium; Complete proteome; Disulfide bond; EGF-like domain; Endocytosis; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4599 AA 
Protein Sequence
MSEFLLALLT LSGLLPIARV LTVGADRDQQ LCDPGEFLCH DHVTCVSQSW LCDGDPDCPD 60
DSDESLDTCP EEVEIKCPLN HIACLGTNKC VHLSQLCNGV LDCPDGYDEG VHCQELLSNC 120
QQLNCQYKCT MVRNSTRCYC EDGFEITEDG RSCKDQDECA VYGTCSQTCR NTHGSYTCSC 180
VEGYLMQPDN RSCKAKIEPT DRPPILLIAN FETIEVFYLN GSKMATLSSV NGNEIHTLDF 240
IYNEDMICWI ESRESSNQLK CIQITKAGGL TDEWTINILQ SFHNVQQMAI DWLTRNLYFV 300
DHVGDRIFVC NSNGSVCVTL IDLELHNPKA IAVDPIAGKL FFTDYGNVAK VERCDMDGMN 360
RTRIIDSKTE QPAALALDLV NKLVYWVDLY LDYVGVVDYQ GKNRHTVIQG RQVRHLYGIT 420
VFEDYLYATN SDNYNIVRIN RFNGTDIHSL IKIENAWGIR IYQKRTQPTV RSHACEVDPY 480
GMPGGCSHIC LLSSSYKTRT CRCRTGFNLG SDGRSCKRPK NELFLFYGKG RPGIVRGMDL 540
NTKIADEYMI PIENLVNPRA LDFHAETNYI YFADTTSFLI GRQKIDGTER ETILKDDLDN 600
VEGIAVDWIG NNLYWTNDGH RKTINVARLE KASQSRKTLL EGEMSHPRGI VVDPVNGWMY 660
WTDWEEDEID DSVGRIEKAW MDGFNRQIFV TSKMLWPNGL TLDFHTNTLY WCDAYYDHIE 720
KVFLNGTHRK IVYSGRELNH PFGLSHHGNY VFWTDYMNGS IFQLDLITSE VTLLRHERPP 780
LFGLQIYDPR KQQGDNMCRV NNGGCSTLCL AIPGGRVCAC ADNQLLDENG TTCTFNPGEA 840
LPHICKAGEF RCKNRHCIQA RWKCDGDDDC LDGSDEDSVN CFNHSCPDDQ FKCQNNRCIP 900
KRWLCDGAND CGSNEDESNQ TCTARTCQVD QFSCGNGRCI PRAWLCDRED DCGDQTDEMA 960
SCEFPTCEPL TQFVCKSGRC ISSKWHCDSD DDCGDGSDEV GCVHSCFDNQ FRCSSGRCIP 1020
GHWACDGDND CGDFSDEAQI NCTKEEIHSP AGCNGNEFQC HPDGNCVPDL WRCDGEKDCE 1080
DGSDEKGCNG TIRLCDHKTK FSCWSTGRCI NKAWVCDGDI DCEDQSDEDD CDSFLCGPPK 1140
HPCANDTSVC LQPEKLCNGK KDCPDGSDEG YLCDECSLNN GGCSNHCSVV PGRGIVCSCP 1200
EGLQLNKDNK TCEIVDYCSN HLKCSQVCEQ HKHTVKCSCY EGWKLDVDGE SCTSVDPFEA 1260
FIIFSIRHEI RRIDLHKRDY SLLVPGLRNT IALDFHFNQS LLYWTDVVED RIYRGKLSES 1320
GGVSAIEVVV EHGLATPEGL TVDWIAGNIY WIDSNLDQIE VAKLDGSLRT TLIAGAMEHP 1380
RAIALDPRYG ILFWTDWDAN FPRIESASMS GAGRKTIYKD MKTGAWPNGL TVDHFEKRIV 1440
WTDARSDAIY SALYDGTNMI EIIRGHEYLS HPFAVSLYGS EVYWTDWRTN TLSKANKWTG 1500
QNVSVIQKTS AQPFDLQIYH PSRQPQAPNP CAANDGKGPC SHMCLINHNR SAACACPHLM 1560
KLSSDKKTCY EMKKFLLYAR RSEIRGVDID NPYFNFITAF TVPDIDDVTV IDFDASEERL 1620
YWTDIKTQTI KRAFINGTGL ETVISRDIQS IRGLAVDWVS RNLYWISSEF DETQINVARL 1680
DGSLKTSIIH GIDKPQCLAA HPVRGKLYWT DGNTINMANM DGSNSKILFQ NQKEPVGLSI 1740
DYVENKLYWI SSGNGTINRC NLDGGNLEVI ESMKEELTKA TALTIMDKKL WWADQNLAQL 1800
GTCSKRDGRN PTILRNKTSG VVHMKVYDKE AQQGSNSCQL NNGGCSQLCL PTSETTRTCM 1860
CTVGYYLQKN RMSCQGIESF LMYSVHEGIR GIPLEPSDKM DALMPISGTS FAVGIDFHAE 1920
NDTIYWTDMG FNKISRAKRD QTWKEDIITN GLGRVEGIAV DWIAGNIYWT DHGFNLIEVA 1980
RLNGSFRYVI ISQGLDQPRS IAVHPEKGLL FWTEWGQMPC IGKARLDGSE KVVLVSMGIA 2040
WPNGISIDYE ENKLYWCDAR TDKIERIDLE TGGNREMVLS GSNVDMFSVA VFGAYIYWSD 2100
RAHANGSVRR GHKNDATETI TMRTGLGVNL KEVKIFNRVR EKGTNVCARD NGGCKQLCLY 2160
RGNSRRTCAC AHGYLAEDGV TCLRHEGYLL YSGRTILKSI HLSDETNLNS PIRPYENPRY 2220
FKNVIALAFD YNQRRKGTNR IFYSDAHFGN IQLIKDNWED RQVIVENVGS VEGLAYHRAW 2280
DTLYWTSSTT SSITRHTVDQ TRPGAFDREA VITMSEDDHP HVLALDECQN LMFWTNWNEQ 2340
HPSIMRSTLT GKNAQVVVST DILTPNGLTI DYRAEKLYFS DGSLGKIERC EYDGSQRHVI 2400
VKSGPGTFLS LAVYDNYIFW SDWGRRAILR SNKYTGGDTK ILRSDIPHQP MGIIAVANDT 2460
NSCELSPCAL LNGGCHDLCL LTPNGRVNCS CRGDRILLED NRCVTKNSSC NAYSEFECGN 2520
GECIDYQLTC DGIPHCKDKS DEKLLYCENR SCRRGFKPCY NRRCIPHGKL CDGENDCGDN 2580
SDELDCKVST CATVEFRCAD GTCIPRSARC NQNIDCADAS DEKNCNNTDC THFYKLGVKT 2640
TGFIRCNSTS LCVLPTWICD GSNDCGDYSD ELKCPVQNKH KCEENYFSCP SGRCILNTWI 2700
CDGQKDCEDG RDEFHCDSSC SWNQFACSAQ KCISKHWICD GEDDCGDGLD ESDSICGAIT 2760
CAADMFSCQG SRACVPRHWL CDGERDCPDG SDELSTAGCA PNNTCDENAF MCHNKVCIPK 2820
QFVCDHDDDC GDGSDESPQC GYRQCGTEEF SCADGRCLLN TQWQCDGDFD CPDHSDEAPL 2880
NPKCKSAEQS CNSSFFMCKN GRCIPSGGLC DNKDDCGDGS DERNCHINEC LSKKVSGCSQ 2940
DCQDLPVSYK CKCWPGFQLK DDGKTCVDID ECSSGFPCSQ QCINTYGTYK CLCTDGYEIQ 3000
PDNPNGCKSL SDEEPFLILA DHHEIRKIST DGSNYTLLKQ GLNNVIAIDF DYREEFIYWI 3060
DSSRPNGSRI NRMCLNGSDI KVVHNTAVPN ALAVDWIGKN LYWSDTEKRI IEVSKLNGLY 3120
PTILVSKRLK FPRDLSLDPQ AGYLYWIDCC EYPHIGRVGM DGTNQSVVIE TKISRPMALT 3180
IDYVNRRLYW ADENHIEFSN MDGSHRHKVP NQDIPGVIAL TLFEDYIYWT DGKTKSLSRA 3240
HKTSGADRLS LIYSWHAITD IQVYHSYRQP DVSKHLCMIN NGGCSHLCLL APGKTHTCAC 3300
PTNFYLAADN RTCLSNCTAS QFRCKTDKCI PFWWKCDTVD DCGDGSDEPD DCPEFRCQPG 3360
RFQCGTGLCA LPAFICDGEN DCGDNSDELN CDTHVCLSGQ FKCTKNQKCI PVNLRCNGQD 3420
DCGDEEDERD CPENSCSPDY FQCKTTKHCI SKLWVCDEDP DCADASDEAN CDKKTCGPHE 3480
FQCKNNNCIP DHWRCDSQND CSDNSDEENC KPQTCTLKDF LCANGDCVSS RFWCDGDFDC 3540
ADGSDERNCE TSCSKDQFRC SNGQCIPAKW KCDGHEDCKY GEDEKSCEPA SPTCSSREYI 3600
CASDGCISAS LKCNGEYDCA DGSDEMDCVT ECKEDQFRCK NKAHCIPIRW LCDGIHDCVD 3660
GSDEENCERG GNICRADEFL CNNSLCKLHF WVCDGEDDCG DNSDEAPDMC VKFLCPSTRP 3720
HRCRNNRICL QSEQMCNGID ECGDNSDEDH CGGKLTYKAR PCKKDEFACS NKKCIPMDLQ 3780
CDRLDDCGDG SDEQGCRIAP TEYTCEDNVN PCGDDAYCNQ IKTSVFCRCK PGFQRNMKNR 3840
QCEDLNECLV FGTCSHQCIN VEGSYKCVCD QNFQERNNTC IAEGSEDQVL YIANDTDILG 3900
FIYPFNYSGD HQQISHIEHN SRITGMDVYY QRDMIIWSTQ FNPGGIFYKR IHGREKRQAN 3960
SGLICPEFKR PRDIAVDWVA GNIYWTDHSR MHWFSYYTTH WTSLRYSINV GQLNGPNCTR 4020
LLTNMAGEPY AIAVNPKRGM MYWTVVGDHS HIEEAAMDGT LRRILVQKNL QRPTGLAVDY 4080
FSERIYWADF ELSIIGSVLY DGSNSVVSVS SKQGLLHPHR IDIFEDYIYG AGPKNGVFRV 4140
QKFGHGSVEY LALNIDKTKG VLISHRYKQL DLPNPCLDLA CEFLCLLNPS GATCVCPEGK 4200
YLINGTCNDD SLLDDSCKLT CENGGRCILN EKGDLRCHCW PSYSGERCEV NHCSNYCQNG 4260
GTCVPSVLGR PTCSCALGFT GPNCGKTVCE DFCQNGGTCI VTAGNQPYCH CQPEYTGDRC 4320
QYYVCHHYCV NSESCTIGDD GSVECVCPTR YEGPKCEVDK CVRCHGGHCI INKDSEDIFC 4380
NCTNGKIASS CQLCDGYCYN GGTCQLDPET NVPVCLCSTN WSGTQCERPA PKSSKSDHIS 4440
TRSIAIIVPL VLLVTLITTL VIGLVLCKRK RRTKTIRRQP IINGGINVEI GNPSYNMYEV 4500
DHDHNDGGLL DPGFMIDPTK ARYIGGGPSA FKLPHTAPPI YLNSDLKGPL TAGPTNYSNP 4560
VYAKLYMDGQ NCRNSLGSVD ERKELLPKKI EIGIRETVA 4599 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005041; F:low-density lipoprotein receptor activity; IEA:Compara.
 GO:0015031; P:protein transport; TAS:ProtInc.
 GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR026823; cEGF.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR023415; LDLR_class-A_CS.
 IPR000033; LDLR_classB_rpt.
 IPR002172; LDrepeatLR_classA_rpt. 
Pfam
 PF12662; cEGF
 PF00008; EGF
 PF07645; EGF_CA
 PF00057; Ldl_recept_a
 PF00058; Ldl_recept_b 
SMART
 SM00181; EGF
 SM00179; EGF_CA
 SM00192; LDLa
 SM00135; LY 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS51120; LDLRB 
PRINTS