CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016035
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear pore complex protein Nup214 
Protein Synonyms/Alias
 214 kDa nucleoporin; Nucleoporin Nup214 
Gene Name
 Nup214 
Gene Synonyms/Alias
 Kiaa0023 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
732VGTSEEMKMLRTESDubiquitination[1]
920TTIESHTKPSPRVPGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (By similarity). 
Sequence Annotation
 REPEAT 41 93 Blade 1 (By similarity).
 REPEAT 94 150 Blade 2 (By similarity).
 REPEAT 151 193 Blade 3 (By similarity).
 REPEAT 194 239 Blade 4 (By similarity).
 REPEAT 240 303 Blade 5 (By similarity).
 REPEAT 304 359 Blade 6 (By similarity).
 REPEAT 360 404 Blade 7 (By similarity).
 REGION 41 404 Seven-bladed beta propeller (By
 REGION 479 2071 11 X 5 AA approximate repeats.
 REGION 734 762 Leucine-zipper 1.
 REGION 855 876 Leucine-zipper 2.
 REGION 1421 2079 18 X 4 AA approximate repeats.
 REGION 1439 2080 11 X 3 AA approximate repeats.
 MOD_RES 430 430 Phosphoserine (By similarity).
 MOD_RES 433 433 Phosphoserine (By similarity).
 MOD_RES 437 437 Phosphothreonine (By similarity).
 MOD_RES 645 645 Phosphoserine (By similarity).
 MOD_RES 651 651 Phosphoserine (By similarity).
 MOD_RES 660 660 Phosphoserine (By similarity).
 MOD_RES 672 672 Phosphoserine (By similarity).
 MOD_RES 930 930 Phosphoserine.
 MOD_RES 960 960 Phosphoserine (By similarity).
 MOD_RES 964 964 Phosphoserine (By similarity).
 MOD_RES 979 979 Phosphoserine (By similarity).
 MOD_RES 1029 1029 Phosphoserine (By similarity).
 MOD_RES 1051 1051 Phosphoserine (By similarity).
 MOD_RES 1156 1156 Phosphothreonine (By similarity).
 MOD_RES 1162 1162 Phosphothreonine (By similarity).
 MOD_RES 1187 1187 Phosphoserine (By similarity).
 MOD_RES 1324 1324 Phosphothreonine (By similarity).
 MOD_RES 1980 1980 Phosphoserine (By similarity).  
Keyword
 Coiled coil; Complete proteome; Glycoprotein; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Repeat; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2085 AA 
Protein Sequence
MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS VLTISNKYGM LFAGGTNGLN 60
VFPTKSLLIQ NKPGDDPNKI VDTIQGLNVP MKFPVHHLAL SCDSLTLSAC MMSSEYGSII 120
AFFDVRTFSN QAKPLKRPFT YHKVSNDASG MVNDMKWNPT VPSMVAVCLA DGSISVLQVT 180
DVVKVCATLP PSTGVTCVCW SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP 240
VRVLDVLWIG TYVFTIVYAG ADGTLETCPD VVMALLPKKE EKHPEIFVNF MEPCYSSCTE 300
RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQNDQTNWES WLLEDSSRAE LPVTDKSDDS 360
LPMGVAIDYT NEVEVTINEE KTLPPAPVLL LLSTDGVLCP FYMINQNPGV RSLIKTLELI 420
STEGERQPKS SGSFPGTPSS PQAPQNLDAP ATASSPLPPV SAAPTSTFPM PSAAGSPSVF 480
SFGPSSFKSS ASVTGEPPLY PTGSDSSRAA PGSGTSTFSF APPSKGSLAS TPAVAPVATS 540
AAPFTFGFKP TLESTPMSST PNTGMKPSFP PSASSVKVNL NEKFTAVASS APVHSSTSTP 600
SVLPFSSSPK PTASGPLSHP TPLPASSSSM PLKSSVSPSP AAGRSTQTAP SSAPSTGQKS 660
PRVNPPVPKS GSSQAKALQP PVTEKQRPQW KDSDPVLAGI GEEIAHFQKE LEELKARTAK 720
ACLQVGTSEE MKMLRTESDD LHTFLFEIRE TTESLHGDIS TLKTTLLEGF AGVEEAREQH 780
GRNHDSGYLH LLYKRPLDPK SEAQLQEIRR LHQYVKFAVQ DVNDVLDLEW DRHLEQKKRQ 840
RRLIVPERET LFNTLANNRE IINQQRKRLN QLVDSLQQLR LYNHTAPWSL PSALSTQSNS 900
HSFDSDLECL LKTTIESHTK PSPRVPGKLS PAKQAQLRNF LAKRKTPPVR STAPASLSRS 960
AFLSQRYYED LDEGSSASSV AQPLEGEDAR PTCTSVAQPL EGEDAQPICK EEEAVVPVPR 1020
HAPVVRTPSI QPSLLPQSMP FAKPHLIHSS SPAVMSSAVS TSATKVIPQG ADSTMLATKT 1080
VKHGAPGPSH TVAAPQAAAA AALRRQMASQ APAMSTLTES TLKTVPQVVN VQELRSNPSP 1140
PSAAMGSAVQ HSAAKTPHAV LTPVANSQAK QGSLINSFKP SGPTAASCQL SSGDKAVGQG 1200
TAKTESAATS TPSAAGQLNK PFSFASPGTF TFGTITPTPS SSFTATPGAG PPTKEPTQLE 1260
AFSFGGGGKP FSEAIPGNSP ATGATSAPST SVTAASLEDS APSSSKPAAP PETTVSSASS 1320
KLETPPSKLG ELLFPSSLAG ETLGSFSGLR VGQAEDSTKP VSKASSTNLA GAQPAKPSGV 1380
SFPNTSVLGK PVEPAVTSSV SPAPAAPASA LNVSTSSSSA TVFGSVPLTS AGPPGLISFG 1440
GAALASSKAS FSFGNQQTSS STASSATPTS TSVAPSLPAS FPTLSFGGLL SSPSASSLPV 1500
SSGKSTEEAA PPAVPDKSDS SEVSATTPSL PVQPQSTQAS LQTSDPVKKE PVLVQTTDSS 1560
PSRPASSASF VASTESMPVT LGAPDSKIEA VSPASTFAGP GQAAVATAVL PGAGSAATEA 1620
SGTPTTSTVS SSSPTSATET AVFGTATSGS SVFTQPPAAS SSSAFSQLSS NTATAPSATP 1680
VFGQVAASIT STAAATPQAS SSGFGSPAFG ASAPGVFGQT AFGQTPAFGQ ATSSPASGFS 1740
FSQPGFSSVP AFGQSVSSTP ASTSANVFGA TSSTSSPGSF SFGQASTNTG GTLFGQNNPP 1800
AFGQSPGFGQ GSSVFGGTSA TTSTAAPSGF SFCQASGFGS SNTGSVFGQA ANTGGSVFGQ 1860
SSTSSGGVFG SGNATRGGGF FSGLGGKPSQ DAANKNPFSS AGGGFGSTAA PNTSNLFGNS 1920
GAKTFGGFGS SSFGEQKPAG TFSSGGGSVA SQGFGFSTPN KTGGFGAAPV FGSPPTFGGS 1980
PGFGGVPAFG SAPAFTSPLG STGGKVFGEG TAAASAGGFG FGSSGNTASF GTLASQNAPT 2040
FGSLSQQTSG FGTPSSGFAG FGSGTGAFTF GSSNSSVQGF GGWRS 2085 
Gene Ontology
 GO:0005643; C:nuclear pore; TAS:MGI.
 GO:0005487; F:nucleocytoplasmic transporter activity; IMP:MGI.
 GO:0006406; P:mRNA export from nucleus; IMP:MGI.
 GO:0006611; P:protein export from nucleus; IEA:Compara.
 GO:0006606; P:protein import into nucleus; IMP:MGI.
 GO:0051726; P:regulation of cell cycle; IMP:MGI. 
Interpro
 IPR026054; Nucleoporin.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
  
PRINTS