CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032296
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein kinase C-binding protein 1 
Protein Synonyms/Alias
 ZMYND8 protein 
Gene Name
 ZMYND8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
351YVENIRRKFGVFNYSubiquitination[1]
408SPKILMSKPVLSGGTacetylation[2, 3, 4]
877RLIAEVKKQLELEKQubiquitination[5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1054 AA 
Protein Sequence
MHPQSLAEEE IKTEQEVVEG MDISTRSKDP GSAERTAQKR KFPSPPHSSN GHSPQDTSTS 60
PIKKKKKPGL LNSNNKEQDG RNDFYCWVCH REGQVLCCEL CPRVYHAKCL RLTSEPEGDW 120
FCPECEKITV AECIETQSKA MTMLTIEQLS YLLKFAIQKM KQPGTDAFQK PVPLEQHPDY 180
AEYIFHPMDL CTLEKNAKKK MYGCTEAFLA DAKWILHNCI IYNGGNHKLT QIAKVVIKIC 240
EHEMNEIEVC PECYLAACQK RDNWFCEPCS NPHPLVWAKL KGFPFWPAKA LRDKDGQVDA 300
RFFGQHDRAW VPINNCYLMS KEIPFSVKKT KSIFNSAMQE MEVYVENIRR KFGVFNYSPF 360
RTPYTPNSQY QMLLDPTNPS AGTAKIDKQE KVKLNFDMTA SPKILMSKPV LSGGTGRRIS 420
LSDMPRSPMS TNSSVHTGSD VEQDAEKKAT SSHFSASEES MDFLDKSTAS PASTKTGQAG 480
SLSGSPKPFS PQLSAPITTK TDKTSTTGSI LNLNLDRSKA EMDLKELSES VQQQSTPVPL 540
ISPKRQIRSR FQLNLDKTIE SCKAQLGINE ISEDVYTAVE HSDSEDSEKS DSSDSEYISD 600
DEQKSKNEPE DTEDKEGCQM DKEPSAVKKK PKPTNPVEIK EELKSTSPAS EKADPGAVKD 660
KASPEPEKDF SEKAKPSPHP IKDKLKGKDE TDSPTVHLGL DSDSESELVI DLGEDHSGRE 720
GRKNKKEPKE PSPKQDAVQQ KEITQSPSTS TITLVTSTQS SPLVTSSGSM STLVSSVNAD 780
LPIATASADV AADIAKYTSK MMDAIKGTMT EIYNDLSKNT TGSTIAEIRR LRIEIEKLQW 840
LHQQELSEMK HNLELTMAEM RQSLEQERDR LIAEVKKQLE LEKQQAVDET KKKQWCANCK 900
KEAIFYCCWN TSYCDYPCQQ AHWPEHMKSC TQSATAPQQE ADAEVNTETL NKSSQGSSSS 960
TQSAPSETAS ASKEKETSAE KSKESGSTLD LSGSRETPSS ILLGSNQGSD HSRSNKSSWS 1020
SSDEKRGSTR SDHNTSTSTK SLLPKESRLD TFWD 1054 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001487; Bromodomain.
 IPR021931; DUF3544.
 IPR000313; PWWP.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR002893; Znf_MYND.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00439; Bromodomain
 PF12064; DUF3544
 PF00628; PHD
 PF00855; PWWP
 PF01753; zf-MYND 
SMART
 SM00297; BROMO
 SM00249; PHD 
PROSITE
 PS50014; BROMODOMAIN_2
 PS50812; PWWP
 PS01360; ZF_MYND_1
 PS50865; ZF_MYND_2
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS
 PR00503; BROMODOMAIN.