| Tag | Content |
|---|
| CPLM ID | CPLM-023365 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein squeeze |
Protein Synonyms/Alias | |
Gene Name | sqz |
Gene Synonyms/Alias | CG5557 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 40 | AQLVHDYKPFNISEF | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Transcription factor involved in neuronal fate specification. First required in embryonic CNS development to define the number of cells that express apterous (ap) in the ap thoracic cluster of interneurons. Later on, it plays a central role in the combinatorial code of transcription factors that specifies the fate of the Tv neuron in the ap cluster by participating in the transcription regulation of FMRFa in Tv cells. Also required for projection neuron dendritic targeting. |
Sequence Annotation | ZN_FING 158 180 C2H2-type 1.
ZN_FING 186 208 C2H2-type 2.
ZN_FING 214 238 C2H2-type 3.
ZN_FING 244 266 C2H2-type 4.
ZN_FING 275 297 C2H2-type 5.
MOD_RES 395 395 Phosphothreonine.
MOD_RES 399 399 Phosphoserine.
MOD_RES 401 401 Phosphoserine.
MOD_RES 475 475 Phosphoserine.
MOD_RES 479 479 Phosphotyrosine.
MOD_RES 481 481 Phosphotyrosine. |
Keyword | Complete proteome; Developmental protein; Differentiation; Metal-binding; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 535 AA |
Protein Sequence | MAELPTAPNG VPSGDYLHRS IDQLRSLGHL TTAQLVHDYK PFNISEFRQN VAERLDYSLK 60
NGLVQHQQQM VMEQQPHPDQ QQQQHLHHPQ QQQHPPQLKV SYSAPNSPPT PHEQQEQKYD 120
PNRSPPRQQM SSASGSGSNG SSPEEESRRG DGDQAKPYKC GSCSKSFANS SYLSQHTRIH 180
LGIKPYRCEI CQRKFTQLSH LQQHIRTHTG DKPYKCRHAG CPKAFSQLSN LQSHSRCHQT 240
DKPFKCNSCY KCFSDEMTLL EHIPKHKDSK HLKTHICNLC GKSYTQETYL QKHLQKHAEK 300
AEKQQHRHTA QVAAHQQHVP ASGIGLNLQR QAMNDVNAAY WAKMGADSAA ASLAEAIQQQ 360
LPQAGGQPYG NFASLQQQHQ QQQQELLHHQ RLADTPGHSH SPHEEAAGED LVLRQSTPQH 420
HLQQQQQQQQ QQQAQQQQQA QHQPSPGPGN SAFTPLSATV APPPHLQQHR GPPGSAAAYL 480
YQQNAAAAAA AFPTQLISLH QIRNYAHQPG AAGLIAGDHL ALGLSAVNAA KEKAQ 535 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0070983; P:dendrite guidance; IMP:FlyBase. GO:0007517; P:muscle organ development; IMP:FlyBase. GO:0014019; P:neuroblast development; IMP:FlyBase. GO:0048477; P:oogenesis; IMP:FlyBase. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |