CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025392
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin-10 
Protein Synonyms/Alias
  
Gene Name
 Myh10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
71QADWTAKKLVWIPSEacetylation[1]
143ASVLHNLKDRYYSGLacetylation[1]
227GKTENTKKVIQYLAHacetylation[2]
227GKTENTKKVIQYLAHsuccinylation[2]
227GKTENTKKVIQYLAHubiquitination[3]
269LESFGNAKTVKNDNSubiquitination[3]
609KPRQLKDKADFCIIHacetylation[1, 2, 4]
620CIIHYAGKVDYKADEacetylation[1]
624YAGKVDYKADEWLMKacetylation[1, 2]
624YAGKVDYKADEWLMKsuccinylation[2]
624YAGKVDYKADEWLMKubiquitination[3]
695RTVGQLYKESLTKLMacetylation[1, 2]
695RTVGQLYKESLTKLMsuccinylation[2]
726NHEKRAGKLDPHLVLubiquitination[3]
894QEEELQAKDEELLKVubiquitination[3]
1058QLAEEEEKAKNLAKIacetylation[2]
1271QGLETDNKELACEVKacetylation[1]
1278KELACEVKVLQQVKAacetylation[1, 2]
1338TLLEEAEKKGIKFAKacetylation[2]
1436EAKKKLLKDVEALSQacetylation[2]
1454EKVLAYDKLEKTKNRacetylation[2]
1682KARDEVIKQLRKLQAacetylation[1]
1837QNKELKAKLQELEGAacetylation[1]
1850GAVKSKFKATISALEacetylation[2]
1850GAVKSKFKATISALEsuccinylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; ATP-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2013 AA 
Protein Sequence
MRMEIWGWGC RDQLLVALDP WKRGVGRGNY FWVLLFTMAQ RTGLEDPERY LFVDRAVIYN 60
PATQADWTAK KLVWIPSERH GFEAASIKEE RGDEVMVELA ENGKKAMVNK DDIQKMNPPK 120
FSKVEDMAEL TCLNEASVLH NLKDRYYSGL IYTYSGLFCV VINPYKNLPI YSENIIEMYR 180
GKKRHEMPPH IYAISESAYR CMLQDREDQS ILCTGESGAG KTENTKKVIQ YLAHVASSHK 240
GRKDHNIPGE LERQLLQANP ILESFGNAKT VKNDNSSRFG KFIRINFDVT GYIVGANIET 300
YLLEKSRAVR QAKDERTFHI FYQLLSGAGE HLKSDLLLEG FNNYRFLSNG YIPIPGQQDK 360
DNFQETMEAM HIMGFSHEEI LSMLKVVSSV LQFGNISFKK ERNTDQASMP ENTVAQKLCH 420
LLGMNVMEFT RAILTPRIKV GRDYVQKAQT KEQADFAVEA LAKATYERLF RWLVHRINKA 480
LDRTKRQGAS FIGILDIAGF EIFELNSFEQ LCINYTNEKL QQLFNHTMFI LEQEEYQREG 540
IEWNFIDFGL DLQPCIDLIE RPANPPGVLA LLDEECWFPK ATDKTFVEKL VQEQGSHSKF 600
QKPRQLKDKA DFCIIHYAGK VDYKADEWLM KNMDPLNDNV ATLLHQSSDR FVAELWKDVD 660
RIVGLDQVTG MTETAFGSAY KTKKGMFRTV GQLYKESLTK LMATLRNTNP NFVRCIIPNH 720
EKRAGKLDPH LVLDQLRCNG VLEGIRICRQ GFPNRIVFQE FRQRYEILTP NAIPKGFMDG 780
KQACERMIRA LELDPNLYRI GQSKIFFRAG VLAHLEEERD LKITDIIIFF QAVCRGYLAR 840
KAFAKKQQQL SALKVLQRNC AAYLKLRHWQ WWRVFTKVKP LLQVTRQEEE LQAKDEELLK 900
VKEKQTKVEG ELEEMERKHQ QLLEEKNILA EQLQAETELF AEAEEMRARL AAKKQELEEI 960
LHDLESRVEE EEERNQILQN EKKKMQAHIQ DLEEQLDEEE GARQKLQLEK VTAEAKIKKM 1020
EEEVLLLEDQ NSKFIKEKKL MEDRIAECSS QLAEEEEKAK NLAKIRNKQE VMISDLEERL 1080
KKEEKTRQEL EKAKRKLDGE TTDLQDQIAE LQAQVDELKV QLTKKEEELQ GALARGDDET 1140
LHKNNALKVA RELQAQIAEL QEDFESEKAS RNKAEKQKRD LSEELEALKT ELEDTLDTTA 1200
AQQELRTKRE QEVAELKKAL EDETKNHEAQ IQDMRQRHAT ALEELSEQLE QAKRFKANLE 1260
KNKQGLETDN KELACEVKVL QQVKAESEHK RKKLDAQVQE LHAKVSEGDR LRVELAEKAN 1320
KLQNELDNVS TLLEEAEKKG IKFAKDAAGL ESQLQDTQEL LQEETRQKLN LSSRIRQLEE 1380
EKNSLQEQQE EEEEARKNLE KQVLALQSQL ADTKKKVDDD LGTIESLEEA KKKLLKDVEA 1440
LSQRLEEKVL AYDKLEKTKN RLQQELDDLT VDLDHQRQIV SNLEKKQKKF DQLLAEEKGI 1500
SARYAEERDR AEAEAREKET KALSLARALE EALEAKEEFE RQNKQLRADM EDLMSSKDDV 1560
GKNVHELEKS KRALEQQVEE MRTQLEELED ELQATEDAKL RLEVNMQAMK AQFERDLQTR 1620
DEQNEEKKRL LLKQVRELEA ELEDERKQRA LAVASKKKME IDLKDLEAQI EAANKARDEV 1680
IKQLRKLQAQ MKDYQRELEE ARASRDEIFA QSKESEKKLK SLEAEILQLQ EELASSERAR 1740
RHAEQERDEL ADEIANSASG KSALLDEKRR LEARIAQLEE ELEEEQSNME LLNDRFRKTT 1800
LQVDTLNTEL AAERSAAQKS DNARQQLERQ NKELKAKLQE LEGAVKSKFK ATISALEAKI 1860
GQLEEQLEQE AKERAAANKL VRRTEKKLKE IFMQVEDERR HADQYKEQME KANARMKQLK 1920
RQLEEAEEEA TRANASRRKL QRELDDATEA NEGLSREVST LKNRLRRGGP ISFSSSRSGR 1980
RQLHIEGASL ELSDDDTESK TSDVNDTQPP QSE 2013 
Gene Ontology
 GO:0030424; C:axon; IDA:MGI.
 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0043197; C:dendritic spine; IDA:MGI.
 GO:0030426; C:growth cone; IDA:MGI.
 GO:0016460; C:myosin II complex; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0001725; C:stress fiber; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro.
 GO:0007512; P:adult heart development; IMP:MGI.
 GO:0007411; P:axon guidance; IMP:MGI.
 GO:0055003; P:cardiac myofibril assembly; IMP:MGI.
 GO:0008283; P:cell proliferation; IMP:MGI.
 GO:0021680; P:cerebellar Purkinje cell layer development; IMP:MGI.
 GO:0006887; P:exocytosis; IMP:MGI.
 GO:0021592; P:fourth ventricle development; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0021670; P:lateral ventricle development; IMP:MGI.
 GO:0000281; P:mitotic cytokinesis; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0007097; P:nuclear migration; IMP:MGI.
 GO:0001778; P:plasma membrane repair; IMP:MGI.
 GO:0008360; P:regulation of cell shape; IMP:MGI.
 GO:0060041; P:retina development in camera-type eye; IMP:MGI.
 GO:0006930; P:substrate-dependent cell migration, cell extension; IMP:MGI.
 GO:0021678; P:third ventricle development; IMP:MGI.
 GO:0055015; P:ventricular cardiac muscle cell development; IMP:MGI. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR008989; Myosin_S1_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00612; IQ
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.