CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017330
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Jouberin 
Protein Synonyms/Alias
 Abelson helper integration site 1 protein homolog; AHI-1 
Gene Name
 AHI1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
381HTGQYVKKDDSGRPVubiquitination[1]
682DGTARIWKNEINNTNubiquitination[1]
999SCAAKVNKNLSFTSPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity). 
Sequence Annotation
 REPEAT 607 649 WD 1.
 REPEAT 652 691 WD 2.
 REPEAT 695 735 WD 3.
 REPEAT 742 781 WD 4.
 REPEAT 797 837 WD 5.
 REPEAT 841 880 WD 6.
 REPEAT 885 926 WD 7.
 DOMAIN 1051 1111 SH3.  
Keyword
 3D-structure; Alternative splicing; Cell junction; Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Joubert syndrome; Reference proteome; Repeat; SH3 domain; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1196 AA 
Protein Sequence
MPTAESEAKV KTKVRFEELL KTHSDLMREK KKLKKKLVRS EENISPDTIR SNLHYMKETT 60
SDDPDTIRSN LPHIKETTSD DVSAANTNNL KKSTRVTKNK LRNTQLATEN PNGDASVEED 120
KQGKPNKKVI KTVPQLTTQD LKPETPENKV DSTHQKTHTK PQPGVDHQKS EKANEGREET 180
DLEEDEELMQ AYQCHVTEEM AKEIKRKIRK KLKEQLTYFP SDTLFHDDKL SSEKRKKKKE 240
VPVFSKAETS TLTISGDTVE GEQKKESSVR SVSSDSHQDD EISSMEQSTE DSMQDDTKPK 300
PKKTKKKTKA VADNNEDVDG DGVHEITSRD SPVYPKCLLD DDLVLGVYIH RTDRLKSDFM 360
ISHPMVKIHV VDEHTGQYVK KDDSGRPVSS YYEKENVDYI LPIMTQPYDF KQLKSRLPEW 420
EEQIVFNENF PYLLRGSDES PKVILFFEIL DFLSVDEIKN NSEVQNQECG FRKIAWAFLK 480
LLGANGNANI NSKLRLQLYY PPTKPRSPLS VVEAFEWWSK CPRNHYPSTL YVTVRGLKVP 540
DCIKPSYRSM MALQEEKGKP VHCERHHESS SVDTEPGLEE SKEVIKWKRL PGQACRIPNK 600
HLFSLNAGER GCFCLDFSHN GRILAAACAS RDGYPIILYE IPSGRFMREL CGHLNIIYDL 660
SWSKDDHYIL TSSSDGTARI WKNEINNTNT FRVLPHPSFV YTAKFHPAVR ELVVTGCYDS 720
MIRIWKVEMR EDSAILVRQF DVHKSFINSL CFDTEGHHMY SGDCTGVIVV WNTYVKINDL 780
EHSVHHWTIN KEIKETEFKG IPISYLEIHP NGKRLLIHTK DSTLRIMDLR ILVARKFVGA 840
ANYREKIHST LTPCGTFLFA GSEDGIVYVW NPETGEQVAM YSDLPFKSPI RDISYHPFEN 900
MVAFCAFGQN EPILLYIYDF HVAQQEAEMF KRYNGTFPLP GIHQSQDALC TCPKLPHQGS 960
FQIDEFVHTE SSSTKMQLVK QRLETVTEVI RSCAAKVNKN LSFTSPPAVS SQQSKLKQSN 1020
MLTAQEILHQ FGFTQTGIIS IERKPCNHQV DTAPTVVALY DYTANRSDEL TIHRGDIIRV 1080
FFKDNEDWWY GSIGKGQEGY FPANHVASET LYQELPPEIK ERSPPLSPEE KTKIEKSPAP 1140
QKQSINKNKS QDFRLGSESM THSEMRKEQS HEDQGHIMDT RMRKNKQAGR KVTLIE 1196 
Gene Ontology
 GO:0005912; C:adherens junction; IDA:UniProtKB.
 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0005814; C:centriole; ISS:UniProtKB.
 GO:0005932; C:microtubule basal body; IDA:UniProtKB.
 GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB.
 GO:0034613; P:cellular protein localization; ISS:UniProtKB.
 GO:0042384; P:cilium assembly; ISS:UniProtKB.
 GO:0035844; P:cloaca development; ISS:UniProtKB.
 GO:0001947; P:heart looping; ISS:UniProtKB.
 GO:0030902; P:hindbrain development; ISS:UniProtKB.
 GO:0070121; P:Kupffer's vesicle development; ISS:UniProtKB.
 GO:0070986; P:left/right axis specification; ISS:UniProtKB.
 GO:0001738; P:morphogenesis of a polarized epithelium; ISS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0071599; P:otic vesicle development; ISS:UniProtKB.
 GO:0035845; P:photoreceptor cell outer segment organization; ISS:UniProtKB.
 GO:0030862; P:positive regulation of polarized epithelial cell differentiation; ISS:UniProtKB.
 GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0039023; P:pronephric duct morphogenesis; ISS:UniProtKB.
 GO:0039008; P:pronephric nephron tubule morphogenesis; ISS:UniProtKB.
 GO:0033365; P:protein localization to organelle; IEA:Compara.
 GO:0050795; P:regulation of behavior; ISS:UniProtKB.
 GO:0010842; P:retina layer formation; ISS:UniProtKB.
 GO:0065001; P:specification of axis polarity; ISS:UniProtKB.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISS:UniProtKB.
 GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB. 
Interpro
 IPR001452; SH3_domain.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00018; SH3_1
 PF00400; WD40 
SMART
 SM00326; SH3
 SM00320; WD40 
PROSITE
 PS50002; SH3
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00452; SH3DOMAIN.