CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015410
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 205 
Protein Synonyms/Alias
  
Gene Name
 TMEM205 
Gene Synonyms/Alias
 UNQ501/PRO1018 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
122WALQTVEKERGLGGEubiquitination[1, 2]
149QLREKDPKYSALRQNacetylation[3]
149QLREKDPKYSALRQNubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861
Functional Description
 In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin. 
Sequence Annotation
 MOD_RES 149 149 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 189 AA 
Protein Sequence
MEEGGNLGGL IKMVHLLVLS GAWGMQMWVT FVSGFLLFRS LPRHTFGLVQ SKLFPFYFHI 60
SMGCAFINLC ILASQHAWAQ LTFWEASQLY LLFLSLTLAT VNARWLEPRT TAAMWALQTV 120
EKERGLGGEV PGSHQGPDPY RQLREKDPKY SALRQNFFRY HGLSSLCNLG CVLSNGLCLA 180
GLALEIRSL 189 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR025423; DUF4149. 
Pfam
 PF13664; DUF4149 
SMART
  
PROSITE
  
PRINTS