UniProt Accession

 OTC_BACSU; P18186 

Genbank Protein ID

 X53360; Z26919; AL009126; D86376 

Genbank Nucleotide ID

 CAA37444.1; CAA81542.1; CAB12966.1; BAA22924.1 

Protein Name

 Ornithine carbamoyltransferase 

Protein Synonyms/Alias

 OTCase 

Gene Name

 argF 

Gene Synonyms/Alias

 BSU11250 

Created Date

 July 27, 2013 

Organism

 Bacillus subtilis (strain 168) 

NCBI Taxa ID

 224308 

Lysine Modification

Position	Peptide	Type	References
81	SALFLSQKDLQLGRG	acetylation	[1]

Reference

 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 

Functional Description

 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline (By similarity). 

Sequence Annotation

 REGION 57 61 Carbamoyl phosphate binding (By
 REGION 135 138 Carbamoyl phosphate binding (By
 REGION 234 235 Ornithine binding (By similarity).
 REGION 269 272 Carbamoyl phosphate binding (By
 BINDING 15 15 Carbamoyl phosphate (By similarity).
 BINDING 84 84 Carbamoyl phosphate (By similarity).
 BINDING 108 108 Carbamoyl phosphate (By similarity).
 BINDING 166 166 Ornithine (By similarity).
 BINDING 230 230 Ornithine (By similarity).
 BINDING 280 280 Carbamoyl phosphate (By similarity).
 BINDING 298 298 Carbamoyl phosphate (By similarity).  

Keyword

 Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 319 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016597; F:amino acid binding; IEA:InterPro.
 GO:0004585; F:ornithine carbamoyltransferase activity; IEA:HAMAP.
 GO:0006526; P:arginine biosynthetic process; IEA:HAMAP. 

Interpro

 IPR006132; Asp/Orn_carbamoyltranf_P-bd.
 IPR006130; Asp/Orn_carbamoylTrfase.
 IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
 IPR002292; Orn/put_carbamltrans.
 IPR024904; Orn_carbamltrans. 

Pfam

 PF00185; OTCace
 PF02729; OTCace_N 

SMART

  

PROSITE

 PS00097; CARBAMOYLTRANSFERASE 

PRINTS

 PR00100; AOTCASE.
 PR00102; OTCASE.