| Tag | Content |
|---|
| CPLM ID | CPLM-007036 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Target of rapamycin complex 1 subunit KOG1 |
Protein Synonyms/Alias | TORC1 subunit KOG1; Kontroller of growth protein 1; Local anesthetic-sensitive protein 24 |
Gene Name | KOG1 |
Gene Synonyms/Alias | LAS24; YHR186C; H9998.14 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 475 | KSNAQDTKAGSIQTQ | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. KOG1 may have a role in binding and recruiting substrates of TORC1. |
Sequence Annotation | REPEAT 548 586 HEAT 1.
REPEAT 588 625 HEAT 2.
REPEAT 777 814 HEAT 3.
REPEAT 888 925 HEAT 4.
REPEAT 1207 1248 WD 1.
REPEAT 1252 1293 WD 2.
REPEAT 1296 1346 WD 3.
REPEAT 1350 1390 WD 4.
REPEAT 1400 1440 WD 5.
REPEAT 1452 1492 WD 6.
REPEAT 1517 1557 WD 7. |
Keyword | Cell membrane; Complete proteome; Membrane; Reference proteome; Repeat; Vacuole; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1557 AA |
Protein Sequence | MPEIYGPQPL KPLNTVMRHG FEEQYQSDQL LQSLANDFIF YFDDKRHKTN GNPIPEEDKQ 60
RDVNRYYQPI TDWKIMKDRQ KTVSAALLLC LNLGVDPPDV MKTHPCARVE AWVDPLNFQD 120
SKKAIEQIGK NLQAQYETLS LRTRYKQSLD PCVEDVKRFC NSLRRTSKED RILFHYNGHG 180
VPKPTKSGEI WVFNRGYTQY IPVSLYDLQT WLGAPCIFVY DCNSAENILI NFQKFVQKRI 240
KDDEEGNHDV AAPSPTSAYQ DCFQLASCTS DELLLMSPEL PADLFSCCLT CPIEISIRIF 300
LMQSPLKDSK YKIFFENSTS NQPFGDSKNS FKSKIPNVNI PGMLSDRRTP LGELNWIFTA 360
ITDTIAWTSL PRPLFKKLFR HDLMIAALFR NFLLAKRIMP WYNCHPVSDP ELPDSITTHP 420
MWKSWDLAMD EVLTKIVIDL KNAPPATALE SQMILQQQET LQNGGSSKSN AQDTKAGSIQ 480
TQSRFAVANL STMSLVNNPA LQSRKSISLQ SSQQQLQQQQ QQQQQFTGFF EQNLTAFELW 540
LKYASNVRHP PEQLPIVLQV LLSQVHRIRA LVLLSRFLDL GPWAVYLSLS IGIFPYVLKL 600
LQSPAPELKP ILVFIWARIM SIDYKNTQSE LIKEKGYMYF VTVLVPDWGV NGMSATNGSA 660
MINSGNPLTM TASQNINGPS SRYYERQQGN RTSNLGHNNL PFYHSNDTTD EQKAMAVFVL 720
ASFVRNFPLG QKNCFSLELV NKLCFYIDNS EIPLLRQWCV ILLGLLFADN PLNRFVCMNT 780
GAVEILLKSL KDPVPEVRTA SIFALKHFIS GFQDAEVILR LQQEFEEQYQ QLHSQLQHLQ 840
NQSHLQQQQS QQQQQHLEQQ QMKIEKQIRH CQVMQNQLEV IDLRKLKRQE IGNLISILPL 900
INDGSSLVRK ELVVYFSHIV SRYSNFFIVV VFNDLLEEIK LLEKSDINTR NTSDKYSVSQ 960
GSIFYTVWKS LLILAEDPFL ENKELSKQVI DYILLELSAH KELGGPFAVM EKFLLKRSSK 1020
AHQTGKFGFN SSQVQFVKSS LRSFSPNERV DNNAFKKEQQ QHDPKISHPM RTSLAKLFQS 1080
LGFSESNSDS DTQSSNTSMK SHTSKKGPSG LYLLNGNNNI YPTAETPRFR KHTEPLQLPL 1140
NSSFLDYSRE YFQEPQMKKQ EADEPGSVEY NARLWRRNRN ETIIQETQGE KKLSIYGNWS 1200
KKLISLNNKS QPKLMKFAQF EDQLITADDR STITVFDWEK GKTLSKFSNG TPFGTKVTDL 1260
KLINEDDSAL LLTGSSDGVI KIYRDYQDVD TFKIVSAWRG LTDMLLTPRS TGLLTEWLQI 1320
RGSLLTTGDV KVIRVWDAHT ETVEVDIPAK TSSLITSLTA DQLAGNIFVA GFADGSLRVY 1380
DRRLDPRDSM IRRWRAGNDK QGVWINNVHL QRGGYRELVS GATNGVVELW DIRSEDPVES 1440
FVDQNVTSQY GSQQKPTTMT CMQVHEHAPI IATGTKQIKI WTTSGDLLNS FKNSHNNGVT 1500
STLAATGIPK SLSYSSTSDA FLSSMAFHPH RMMIAATNSH DSIVNIYKCE DERIDYF 1557 |
Gene Ontology | |
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