UniProt Accession

 DAP1_RAT; Q9QX67 

Genbank Protein ID

 U05334; BC060569 

Genbank Nucleotide ID

 AAF21441.1; AAH60569.1 

Protein Name

 Death-associated protein 1 

Protein Synonyms/Alias

 DAP-1; Rap7a 

Gene Name

 Dap 

Gene Synonyms/Alias

 Rap7a 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
8	MSSPPEGKLETKAGH	acetylation	[1]
29	AGIRIVQKHPHTGDG	acetylation	[1]
37	HPHTGDGKEKKDKDD	acetylation	[1]
54	WESTSPPKPTVYISG	acetylation	[1]
68	GVIARGDKDFPPAAA	acetylation	[1]
81	AAQVAHQKPHASMDK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 3 3 Phosphoserine; by MTOR (By similarity).
 MOD_RES 49 49 Phosphoserine (By similarity).
 MOD_RES 50 50 Phosphothreonine (By similarity).
 MOD_RES 51 51 Phosphoserine; by MTOR (By similarity).
 MOD_RES 91 91 Phosphoserine (By similarity).  

Keyword

 Acetylation; Apoptosis; Autophagy; Complete proteome; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 102 AA 

Protein Sequence

Gene Ontology

 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0097190; P:apoptotic signaling pathway; IEA:Compara.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0034198; P:cellular response to amino acid starvation; IEA:Compara.
 GO:0010507; P:negative regulation of autophagy; IEA:Compara.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara. 

Interpro

 IPR024130; DAP1/DAPL1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS