CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007110
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisomal targeting signal 2 receptor 
Protein Synonyms/Alias
 PTS2 receptor; Peroxin-7; Peroxisome import protein PAS7 
Gene Name
 PEX7 
Gene Synonyms/Alias
 PAS7; PEB1; YDR142C; YD2943.01C; YD9302.18C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
165NAIILKKKSFTGISKubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes. 
Sequence Annotation
 REPEAT 58 89 WD 1.
 REPEAT 102 133 WD 2.
 REPEAT 172 203 WD 3.
 REPEAT 218 249 WD 4.
 REPEAT 281 312 WD 5.
 REPEAT 340 372 WD 6.  
Keyword
 Complete proteome; Cytoplasm; Peroxisome; Protein transport; Reference proteome; Repeat; Transport; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 375 AA 
Protein Sequence
MLRYHMQGFS GYGVQYSPFF DNRLAVAAGS NFGLVGNGKL FILEIDRSGR IVEVNSFLTQ 60
DCLFDLAWNE SHENQVLVAQ GDGTLRLFDT TFKEFPIAIF KEHEREVFSC NWNLVNRQNF 120
LSSSWDGSIK IWSPLRKQSL MTLTPRPLEI TKMVDPLNAI ILKKKSFTGI SKNRNCVYQA 180
QFSPHDQNLV LSCSGNSYAS LFDIRLPSGK NQNNFLVHSG LEALTCDFNK YRPYVVATGG 240
VDNAIRIWDI RMLNKNESAT IKRTVPGQLH NSSCINEIPN AHGLAIRKVT WSPHHSNILM 300
SASYDMTCRI WRDLSNDGAK ETYKTNSTDA TKGSIFNFTQ HSEFVFGADW SLWGKPGYVA 360
STAWDGNLFV WNGLG 375 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005777; C:peroxisome; IDA:SGD.
 GO:0005053; F:peroxisome matrix targeting signal-2 binding; IDA:SGD.
 GO:0016560; P:protein import into peroxisome matrix, docking; IPI:SGD. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR025651; PEX7-like_WD_rpt.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.