UniProt Accession

 HMGB1_BOVIN; P10103; A5D9G8; Q3ZC39 

Genbank Protein ID

 X12796; BT030587; BC102929; M26110 

Genbank Nucleotide ID

 CAA31284.1; ABQ13027.1; AAI02930.1; AAA30567.1 

Protein Name

 High mobility group protein B1 

Protein Synonyms/Alias

 High mobility group protein 1; HMG-1 

Gene Name

 HMGB1 

Gene Synonyms/Alias

 HMG1 

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
3	*****MGKGDPKKPR	acetylation	[1]
12	DPKKPRGKMSSYAFF	acetylation	[1]

Reference

 [1] Studies of acetylation and deacetylation in high mobility group proteins. Identification of the sites of acetylation in HMG-1.
 Sterner R, Vidali G, Allfrey VG.
 J Biol Chem. 1979 Nov 25;254(22):11577-83. [PMID: 500660] 

Functional Description

 DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). 

Sequence Annotation

 DNA_BIND 9 79 HMG box 1.
 DNA_BIND 95 163 HMG box 2.
 MOD_RES 30 30 N6-acetyllysine (By similarity).
 MOD_RES 35 35 Phosphoserine (By similarity).
 MOD_RES 100 100 Phosphoserine (By similarity).
 CROSSLNK 112 112 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0000793; C:condensed chromosome; ISS:AgBase.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0042056; F:chemoattractant activity; IDA:UniProtKB.
 GO:0003684; F:damaged DNA binding; IDA:UniProtKB.
 GO:0008301; F:DNA binding, bending; IDA:UniProtKB.
 GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.
 GO:0042393; F:histone binding; IDA:UniProtKB.
 GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
 GO:0006288; P:base-excision repair, DNA ligation; ISS:AgBase.
 GO:0006338; P:chromatin remodeling; NAS:UniProtKB.
 GO:0002407; P:dendritic cell chemotaxis; IDA:UniProtKB.
 GO:0006265; P:DNA topological change; IDA:UniProtKB.
 GO:0001773; P:myeloid dendritic cell activation; IDA:UniProtKB.
 GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; ISS:AgBase.
 GO:0033151; P:V(D)J recombination; IDA:UniProtKB. 

Interpro

 IPR009071; HMG_box_dom.
 IPR017967; HMG_boxA_CS. 

Pfam

 PF09011; DUF1898
 PF00505; HMG_box 

SMART

 SM00398; HMG 

PROSITE

 PS00353; HMG_BOX_1
 PS50118; HMG_BOX_2 

PRINTS