UniProt Accession

 NUP54_HUMAN; Q7Z3B4; B2RCK7; Q96EA7; Q9NVL5; Q9P0I1 

Genbank Protein ID

 AF157322; AK001517; AK315160; BX538002; CH471057 

Genbank Nucleotide ID

 AAF67488.1; BAA91735.1; BAG37604.1; CAD97957.1; EAX05777.1 

Protein Name

 Nucleoporin p54 

Protein Synonyms/Alias

 54 kDa nucleoporin 

Gene Name

 NUP54 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
294	ELSPAQIKQLLQNPP	ubiquitination	[1]
321	VDNPDSEKLIPVPMV	ubiquitination	[1]
331	PVPMVGFKELLRRLK	ubiquitination	[1]
338	KELLRRLKVQDQMTK	ubiquitination	[1]
363	EDISELQKNQTTSVA	ubiquitination	[1]
371	NQTTSVAKIAQYKRK	ubiquitination	[1]
398	IKQEIQRKSGYAIQA	ubiquitination	[1]
428	LNAPTQFKGRLNELM	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (By similarity). 

Sequence Annotation

 REPEAT 5 6 1.
 REPEAT 25 26 2.
 REPEAT 28 29 3.
 REPEAT 53 54 4.
 REPEAT 61 62 5.
 REPEAT 63 64 6.
 REPEAT 67 68 7.
 REPEAT 87 88 8.
 REPEAT 444 445 9.
 REGION 5 445 9 X 2 AA repeats of F-G.  

Keyword

 Alternative splicing; Complete proteome; Glycoprotein; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport; Reference proteome; Repeat; Translocation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 507 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005643; C:nuclear pore; TAS:ProtInc.
 GO:0005654; C:nucleoplasm; TAS:ProtInc.
 GO:0005487; F:nucleocytoplasmic transporter activity; IEA:Compara.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
 GO:0015758; P:glucose transport; TAS:Reactome.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0006605; P:protein targeting; IEA:Compara.
 GO:0010827; P:regulation of glucose transport; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 

Interpro

 IPR024864; Nup54/Nup57/Nup44.
 IPR025712; Nup54_alpha-helical_dom. 

Pfam

 PF13874; Nup54 

SMART

  

PROSITE

  

PRINTS