| Tag | Content |
|---|
| CPLM ID | CPLM-011902 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho guanine nucleotide exchange factor 5 |
Protein Synonyms/Alias | Ephexin-3; Guanine nucleotide regulatory protein TIM; Oncogene TIM; Transforming immortalized mammary oncogene; p60 TIM |
Gene Name | ARHGEF5 |
Gene Synonyms/Alias | TIM |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1060 | SRGPAVEKHPGPSDT | ubiquitination | [1] | | 1107 | YSDVVLNKEIQSQQR | ubiquitination | [1] | | 1343 | SEEAEATKAHHALEQ | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | |
Sequence Annotation | DOMAIN 1174 1358 DH.
DOMAIN 1390 1502 PH.
DOMAIN 1513 1569 SH3.
MOD_RES 184 184 Phosphoserine.
MOD_RES 445 445 Phosphoserine.
MOD_RES 450 450 Phosphoserine.
MOD_RES 1126 1126 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Phosphoprotein; Proto-oncogene; Reference proteome; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1597 AA |
Protein Sequence | MEAEEAQRGA SPPISAIEEF SIIPEAPMRS SQVSALGLEA QEDEDPSYKW REEHRLSATQ 60
QSELRDVCDY AIETMPSFPK EGSADVEPNQ ESLVAEACDT PEHWEAVPQS LAGRQARTLA 120
PPELWACPIQ SEHLDMAPFS SDLGSEEEEV EFWPGLTSLT LGSGQAEEEE ETSSDNSGQT 180
RYYSPCEEHP AETNQNEGSE SGTIRQGEEL PPEELQESQG LLHPQEVQVL EEQGQQEAGF 240
RGEGTLREDV CADGLLGEEQ MIEQVNDEKG EQKQKQEQVQ DVMLGRQGER MGLTGEPEGL 300
NDGEWEQEDM ERKAQGQGGP EQGEERKREL QVPEENRADS QDEKSQTFLG KSEEVTGKQE 360
DHGIKEKGVP VSGQEAKEPE SWDGGRLGAV GRARSREEEN EHHGPSMPAL IAPEDSPHCD 420
LFPGASYLMT QIPGTQTESR AEELSPAALS PSLEPIRCSH QPISLLGSFL TEESPDKEID 480
QNSQQEESRL RKGTVSSQGT EVVFASASVT PPRTPDSAPP SPAEAYPITP ASVSARPPVA 540
FPRRETSCAA RAPETASAPL SMDDPSPCGT SEMCPAALYG FPSTGTSPPR PPANSTGTVQ 600
HLRSDSFPGS HRTEQTPDLV GMLLSYSHSE LPQRPPKPAI YSSVTPRRDR RSGRDYSTVS 660
ASPTALSTLK QDSQESISNL ERPSSPPSIQ PWVSPHNPAF ATESPAYGSS PSFVSMEDVR 720
IHEPLPPPPP QRRDTHPSVV ETDGHARVVV PTLKQHSHPP PLALGSGLHA PHKGPLPQAS 780
DPAVARQHRP LPSTPDSSHH AQATPRWRYN KPLPPTPDLP QPHLPPISAP GSSRIYRPLP 840
PLPIIDPPTE PPPLPPKSRG RSRSTRGGHM NSGGHAKTRP ACQDWTVPLP ASAGRTSWPP 900
ATARSTESFT STSRSKSEVS PGMAFSNMTN FLCPSSPTTP WTPELQGPTS KDEAGVSEHP 960
EAPAREPLRR TTPQQGASGP GRSPVGQARQ PEKPSHLHLE KASSWPHRRD SGRPPGDSSG 1020
QAVAPSEGAN KHKGWSRQGL RRPSILPEGS SDSRGPAVEK HPGPSDTVVF REKKPKEVMG 1080
GFSRRCSKLI NSSQLLYQEY SDVVLNKEIQ SQQRLESLSE TPGPSSPRQP RKALVSSESY 1140
LQRLSMASSG SLWQEIPVVR NSTVLLSMTH EDQKLQEVKF ELIVSEASYL RSLNIAVDHF 1200
QLSTSLRATL SNQEHQWLFS RLQDVRDVSA TFLSDLEENF ENNIFSFQVC DVVLNHAPDF 1260
RRVYLPYVTN QTYQERTFQS LMNSNSNFRE VLEKLESDPV CQRLSLKSFL ILPFQRITRL 1320
KLLLQNILKR TQPGSSEEAE ATKAHHALEQ LIRDCNNNVQ SMRRTEELIY LSQKIEFECK 1380
IFPLISQSRW LVKSGELTAL EFSASPGLRR KLNTRPVHLH LFNDCLLLSR PREGSRFLVF 1440
DHAPFSSIRG EKCEMKLHGP HKNLFRLFLR QNTQGAQAEF LFRTETQSEK LRWISALAMP 1500
REELDLLECY NSPQVQCLRA YKPRENDELA LEKADVVMVT QQSSDGWLEG VRLSDGERGW 1560
FPVQQVEFIS NPEVRAQNLK EAHRVKTAKL QLVEQQA 1597 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HPA. GO:0005886; C:plasma membrane; IDA:HPA. GO:0005525; F:GTP binding; TAS:ProtInc. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0030036; P:actin cytoskeleton organization; IEA:Compara. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0002408; P:myeloid dendritic cell chemotaxis; IEA:Compara. GO:0071803; P:positive regulation of podosome assembly; IEA:Compara. GO:0032321; P:positive regulation of Rho GTPase activity; IEA:Compara. GO:0032319; P:regulation of Rho GTPase activity; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |