CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024078
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Krueppel-like factor 5 
Protein Synonyms/Alias
 Basic transcription element-binding protein 2; BTE-binding protein 2; Intestinal-enriched krueppel-like factor; Transcription factor BTEB2 
Gene Name
 Klf5 
Gene Synonyms/Alias
 Bteb2; Iklf 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
151RPCVTQIKTEPVTIFsumoylation[1]
202EVNNIFIKQELPIPDsumoylation[1]
Reference
 [1] SUMOylation regulates nuclear localization of Krüppel-like factor 5.
 Du JX, Bialkowska AB, McConnell BB, Yang VW.
 J Biol Chem. 2008 Nov 14;283(46):31991-2002. [PMID: 18782761] 
Functional Description
 Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. 
Sequence Annotation
 ZN_FING 362 386 C2H2-type 1.
 ZN_FING 392 416 C2H2-type 2.
 ZN_FING 422 444 C2H2-type 3.
 REGION 313 317 Interaction with WWP1 (By similarity).  
Keyword
 Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 446 AA 
Protein Sequence
MPTRVLTMSA RLGPLPQPPA AQDEPVFAQL KPVLGAANPA RDAALFSGDD LKHAHHHPPA 60
PPPAAGPRLP SEELVQTRCE MEKYLTPQLP PVPIISEHKK YRRDSASVVD QFFTDTEGIP 120
YSINMNVFLP DITHLRTGLY KSQRPCVTQI KTEPVTIFSH QSESTAPPPP PAPTQALPEF 180
TSIFSSHQTT APPQEVNNIF IKQELPIPDL HLSVPSQQGH LYQLLNTPDL DMPSSTNQTA 240
VMDTLNVSMA GLNPHPSAVP QTSMKQFQGM PPCTYTMPSQ FLPQQATYFP PSPPSSEPGS 300
PDRQAEMLQN LTPPPSYAAT IASKLAIHNP NLPATLPVNS PTLPPVRYNR RSNPDLEKRR 360
IHFCDYNGCT KVYTKSSHLK AHLRTHTGEK PYKCTWEGCD WRFARSDELT RHYRKHTGAK 420
PFQCMVCQRS FSRSDHLALH MKRHQN 446 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0030033; P:microvillus assembly; IMP:MGI.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:MGI.
 GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS