CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026486
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Slc8a1 protein 
Protein Synonyms/Alias
 Sodium/calcium exchanger 1 
Gene Name
 Slc8a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
283EGDRPASKTEIEMDGubiquitination[1]
356QVLSQQQKSRAFYRIubiquitination[1]
377TGAGNILKRHAADQAubiquitination[1]
572GNVIIPYKTIEGTARubiquitination[1]
606IVKTISVKVIDDEEYubiquitination[1]
615IDDEEYEKNKTFFIEubiquitination[1]
634RLVEMSEKKGGFTLTubiquitination[1]
670ISEEYDDKQPLTSKEubiquitination[1]
713EFKSTVDKLIKKTNLubiquitination[1]
717TVDKLIKKTNLALVVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 958 AA 
Protein Sequence
MLRLSLPPNV SMGFRLVALV ALLFSHVDHI TADTEAETGG NETTECTGSY YCKKGVILPI 60
WEPQDPSFGD KIARATVYFV AMVYMFLGVS IIADRFMSSI EVITSQEKEI TIKKPNGETT 120
KTTVRIWNET VSNLTLMALG SSAPEILLSV IEVCGHNFTA GDLGPSTIVG SAAFNMFIII 180
ALCVYVVPDG ETRKIKHLRV FFVTAAWSIF AYTWLYIILS VSSPGVVEVW EGLLTFFFFP 240
ICVVFAWVAD RRLLFYKYVY KRYRAGKQRG MIIEHEGDRP ASKTEIEMDG KVVNSHVDNF 300
LDGALVLEVD ERDQDDEEAR REMARILKEL KQKHPEKEIE QLIELANYQV LSQQQKSRAF 360
YRIQATRLMT GAGNILKRHA ADQARKAVSM HEVNMEMAEN DPVSKIFFEQ GTYQCLENCG 420
TVALTIMRRG GDLSTTVFVD FRTEDGTANA GSDYEFTEGT VIFKPGETQK EIRVGIIDDD 480
IFEEDENFLV HLSNVRVSSD VSEDGILESN HASSIACLGS PSTATITIFD DDHAGIFTFE 540
EPVTHVSESI GIMEVKVLRT SGARGNVIIP YKTIEGTARG GGEDFEDTCG ELEFQNDEIV 600
KTISVKVIDD EEYEKNKTFF IEIGEPRLVE MSEKKGGFTL TGQPIFRKVH ARDHPIPSTV 660
ITISEEYDDK QPLTSKEEEE RRIAEMGRPI LGEHTKLEVI IEESYEFKST VDKLIKKTNL 720
ALVVGTNSWR EQFIEAITVS AGEDDDDDEC GEEKLPSCFD YVMHFLTVFW KVLFAFVPPT 780
EYWNGWACFI VSILMIGLLT AFIGDLASHF GCTIGLKDSV TAVVFVALGT SVPDTFASKV 840
AATQDQYADA SIGNVTGSNA VNVFLGIGVA WSIAAIYHAA NGEQFKVSPG TLAFSVTLFT 900
IFAFINVGVL LYRRRPEIGG ELGGPRTAKL LTSSLFVLLW LLYIFFSSLE AYCHIKGF 958 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; TAS:MGI.
 GO:0030315; C:T-tubule; IDA:MGI.
 GO:0005432; F:calcium:sodium antiporter activity; IDA:MGI.
 GO:0055013; P:cardiac muscle cell development; IMP:MGI.
 GO:0060048; P:cardiac muscle contraction; IGI:MGI.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0035050; P:embryonic heart tube development; IMP:MGI.
 GO:0001892; P:embryonic placenta development; IMP:MGI.
 GO:0003007; P:heart morphogenesis; IGI:MGI.
 GO:0048747; P:muscle fiber development; IGI:MGI.
 GO:0009791; P:post-embryonic development; IGI:MGI.
 GO:0002026; P:regulation of the force of heart contraction; IMP:MGI. 
Interpro
 IPR003644; Calx_beta.
 IPR001623; DnaJ_domain.
 IPR004836; Na_Ca_Ex.
 IPR002987; NaCa_exhngr1.
 IPR004837; NaCa_Exmemb. 
Pfam
 PF03160; Calx-beta
 PF01699; Na_Ca_ex 
SMART
 SM00237; Calx_beta 
PROSITE
 PS50076; DNAJ_2 
PRINTS
 PR01259; NACAEXCHNGR.
 PR01260; NACAEXCHNGR1.