UniProt Accession

 RHOU_HUMAN; Q7L0Q8; B1AKN1; Q59FE9; Q8TDQ2 

Genbank Protein ID

 AF378087; AB074878; AB051826; DQ384420; DQ384421; DQ384422; DQ384423; DQ384424; DQ384425; AF211836; AF282258; AF251701; AK289971; AB209511; AL096776; CH471098; BC040076 

Genbank Nucleotide ID

 AAK83340.1; BAB86361.1; BAB18638.1; ABD48870.1; ABD48871.1; ABD48872.1; ABD48873.1; ABD48874.1; ABD48875.1; AAL54874.1; AAG46058.1; AAL99390.1; BAF82660.1; BAD92748.1; CAC00584.1; EAW69885.1; AAH40076.1 

Protein Name

 Rho-related GTP-binding protein RhoU 

Protein Synonyms/Alias

 CDC42-like GTPase 1; GTP-binding protein-like 1; Rho GTPase-like protein ARHU; Ryu GTPase; Wnt-1 responsive Cdc42 homolog 1; WRCH-1 

Gene Name

 RHOU 

Gene Synonyms/Alias

 ARHU; CDC42L1; G28K; WRCH1; SB128 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
196	KLCAEEIKAASYIEC	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. 

Sequence Annotation

 NP_BIND 56 63 GTP.
 NP_BIND 103 107 GTP (By similarity).
 NP_BIND 161 164 GTP.
 LIPID 256 256 S-palmitoyl cysteine.  

Keyword

 3D-structure; Alternative splicing; Cell junction; Cell membrane; Cell projection; Complete proteome; Golgi apparatus; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Palmitate; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 258 AA 

Protein Sequence

Gene Ontology

 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0002102; C:podosome; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0030036; P:actin cytoskeleton organization; IEA:Compara.
 GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0016601; P:Rac protein signal transduction; IEA:Compara.
 GO:0008360; P:regulation of cell shape; IMP:UniProtKB.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.