CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001701
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cleft lip and palate transmembrane protein 1 
Protein Synonyms/Alias
  
Gene Name
 CLPTM1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
209RRRFQKTKNLLTGETubiquitination[1, 2, 3]
224EADPEMIKRAEDYGPubiquitination[1, 2, 3]
324LYAAQSTKSPWNFLGubiquitination[2]
436IDLWKITKVMDVRLDubiquitination[2]
458IFPRLSFKDKSTYIEubiquitination[2]
460PRLSFKDKSTYIESSubiquitination[1, 2, 3]
534LFINYKLKSVAHLPWubiquitination[1, 2, 3]
644ASTSLPTKPTQGASSubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May play a role in T-cell development (By similarity). 
Sequence Annotation
 CARBOHYD 28 28 N-linked (GlcNAc...) (Potential).
 CARBOHYD 119 119 N-linked (GlcNAc...) (Potential).
 CARBOHYD 161 161 N-linked (GlcNAc...) (Potential).
 CARBOHYD 241 241 N-linked (GlcNAc...) (Potential).
 CARBOHYD 295 295 N-linked (GlcNAc...).
 CARBOHYD 413 413 N-linked (GlcNAc...) (Potential).  
Keyword
 Chromosomal rearrangement; Complete proteome; Developmental protein; Differentiation; Glycoprotein; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 669 AA 
Protein Sequence
MAAAQEADGA RSAVVAAGGG SSGQVTSNGS IGRDPPAETQ PQNPPAQPAP NAWQVIKGVL 60
FRIFIIWAIS SWFRRGPAPQ DQAGPGGAPR VASRNLFPKD TLMNLHVYIS EHEHFTDFNA 120
TSALFWEQHD LVYGDWTSGE NSDGCYEHFA ELDIPQSVQQ NGSIYIHVYF TKSGFHPDPR 180
QKALYRRLAT VHMSRMINKY KRRRFQKTKN LLTGETEADP EMIKRAEDYG PVEVISHWHP 240
NITINIVDDH TPWVKGSVPP PLDQYVKFDA VSGDYYPIIY FNDYWNLQKD YYPINESLAS 300
LPLRVSFCPL SLWRWQLYAA QSTKSPWNFL GDELYEQSDE EQDSVKVALL ETNPYLLALT 360
IIVSIVHSVF EFLAFKNDIQ FWNSRQSLEG LSVRSVFFGV FQSFVVLLYI LDNETNFVVQ 420
VSVFIGVLID LWKITKVMDV RLDREHRVAG IFPRLSFKDK STYIESSTKV YDDMAFRYLS 480
WILFPLLGCY AVYSLLYLEH KGWYSWVLSM LYGFLLTFGF ITMTPQLFIN YKLKSVAHLP 540
WRMLTYKALN TFIDDLFAFV IKMPVMYRIG CLRDDVVFFI YLYQRWIYRV DPTRVNEFGM 600
SGEDPTAAAP VAEVPTAAGA LTPTPAPTTT TATREEASTS LPTKPTQGAS SASEPQEAPP 660
KPAEDKKKD 669 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; ISS:BHF-UCL.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0033081; P:regulation of T cell differentiation in thymus; ISS:BHF-UCL. 
Interpro
 IPR008429; CLPTM1. 
Pfam
 PF05602; CLPTM1 
SMART
  
PROSITE
  
PRINTS