CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035813
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pyruvate kinase 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
41SRSVEMLKEMIKSGMacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Glycolysis; Kinase; Magnesium; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 469 AA 
Protein Sequence
MTDTFLEHMC RLDIDSAPIT ARNTDIMCTI GPASRSVEML KEMIKSGMNV AWLNFCHRIH 60
EYQAETIKNA SDRILYHPVS VDLIQRDPDE ASRMRHCRGR DDEGSLNNAY MEKSDENILW 120
LDYKNICKVL EVASKIYVDD RLMKEKDADY LVTELENGGS LGSKKGMNLP GAAVDLPAMS 180
GKDIQDLKFG VEQDVDMVFT SFIHAASVHE IRKVLGEKGK NVKTICKIEN REGVSRFDEI 240
VEASDGIMVA YGDLGTEIPA EEVFLAQTQA GKPVICATRM LEGMTRKLHA TCAEGIDVAK 300
TVLDGADCIM LSGETAEGAY PLEAVRMQHL IAHEAEAAIY HLQLFEELAV WHLIEAATEG 360
ALEASFRCCI GASIVLTKSY RSAHQVSRCN PCAPIIVVTS NPQTARQAHL YLGIFPVQDA 420
WTEDIGLHIN LAMNIGKAGG VFKKGDVAIV LTRWHPGCGF TNTVRIVPV 469 
Gene Ontology
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030955; F:potassium ion binding; IEA:InterPro.
 GO:0004743; F:pyruvate kinase activity; IEA:EC.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001697; Pyr_Knase.
 IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
 IPR011037; Pyrv_Knase-like_insert_dom.
 IPR015794; Pyrv_Knase_a/b.
 IPR015793; Pyrv_Knase_brl.
 IPR015795; Pyrv_Knase_C.
 IPR015806; Pyrv_Knase_insert_dom. 
Pfam
 PF00224; PK
 PF02887; PK_C 
SMART
  
PROSITE
  
PRINTS
 PR01050; PYRUVTKNASE.