CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017431
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetratricopeptide repeat protein 39C 
Protein Synonyms/Alias
 TPR repeat protein 39C 
Gene Name
 TTC39C 
Gene Synonyms/Alias
 C18orf17 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53RESDQLFKQYRNHSPubiquitination[1]
416IVFKEVQKLFKRKNNacetylation[2]
419KEVQKLFKRKNNQIEacetylation[2]
513QYFQRAVKDELCRQNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
  
Sequence Annotation
 REPEAT 315 348 TPR 1.
 REPEAT 353 386 TPR 2.
 REPEAT 485 518 TPR 3.  
Keyword
 Alternative splicing; Complete proteome; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 583 AA 
Protein Sequence
MAGSEQQRPR RRDDGDSDAA AAAAAPLQDA ELALAGINML LNNGFRESDQ LFKQYRNHSP 60
LMSFGASFVS FLNAMMTFEE EKMQLACDDL KTTEKLCESE EAGVIETIKN KIKKNVDVRK 120
SAPSMVDRLQ RQIIIADCQV YLAVLSFVKQ ELSAYIKGGW ILRKAWKIYN KCYLDINALQ 180
ELYQKKLTEE SLTSDAANDN HIVAEGVSEE SLNRLKGAVS FGYGLFHLCI SMVPPNLLKI 240
INLLGFPGDR LQGLSSLMYA SESKDMKAPL ATLALLWYHT VVRPFFALDG SDNKAGLDEA 300
KEILLKKEAA YPNSSLFMFF KGRIQRLECQ INSALTSFHT ALELAVDQRE IQHVCLYEIG 360
WCSMIELNFK DAFDSFERLK NESRWSQCYY AYLTAVCQGA TGDVDGAQIV FKEVQKLFKR 420
KNNQIEQFSV KKAERFRKQT PTKALCVLAS IEVLYLWKAL PNCSFPNLQR MSQACHEVDD 480
SSVVGLKYLL LGAIHKCLGN SEDAVQYFQR AVKDELCRQN NLYVQPYACY ELGCLLLDKP 540
ETVGRGRALL LQAKEDFSGY DFENRLHVRI HAALASLREL VPQ 583 
Gene Ontology
  
Interpro
 IPR019412; OMP_IML2_mit/TPR_39.
 IPR011990; TPR-like_helical. 
Pfam
 PF10300; DUF3808 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS