CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020971
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear valosin-containing protein-like 
Protein Synonyms/Alias
 NVLp; Nuclear VCP-like protein 
Gene Name
 Nvl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
70FSIISSEKELKNLKEacetylation[1, 2]
155STPLLTSKTGSVPLKacetylation[1, 2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
 NP_BIND 304 311 ATP (Potential).
 NP_BIND 621 628 ATP (Potential).
 MOTIF 49 52 Nucleolar localization signal.
 MOD_RES 133 133 Phosphoserine (By similarity).
 MOD_RES 137 137 Phosphothreonine (By similarity).
 MOD_RES 210 210 Phosphoserine (By similarity).
 MOD_RES 214 214 Phosphoserine (By similarity).  
Keyword
 3D-structure; ATP-binding; Complete proteome; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 855 AA 
Protein Sequence
MKPRPGVFVD RKLKQRVIQY LSSNRCGKYV DTGILASDLQ RLYSVDYGRR KRNAFRIQVE 60
KVFSIISSEK ELKNLKELED GHLAKRARQD EEDEYTESYS DDDSNMEDYP DPQSANPMNS 120
SLLSLYRRGN SESVSTTPKW GQREATTSTP LLTSKTGSVP LKTPARESEG GWFIDKTPGG 180
KKESLPLDLS DDQSNSKKQD SEIQILKDSS LLESDKKRKG RAKGKGNKRK TENLQEVDGE 240
IEALLQKKAK ARSTELQISN VKFEDVGGND ATLKEVCKML IHMRHPEVYQ HLGVVPPRGV 300
LLHGPPGCGK TLLAHAIAGE LDLPILKVAA PEIVSGVSGE SEQKLRELFD QAVSNAPCIV 360
FIDEIDAITP KREVASKDME RRIVAQLLTC MDDLNNVAAT ARVLVIGATN RPDSLDPALR 420
RAGRFDREVC LGIPDEAARE RILQTLCRKL RLPETFNFCH LAHLTPGFVG ADLMALCREA 480
AMCAVNRVLM KQQAQQKKKP EIEGLPSEGD QEERLGAEPT SETQDELQRL LGLLRDQDPL 540
SEEQMQGLCI ELNDFIVALA EVQPSAKREG FVTVPNVTWA DIGALEDIRD ELIMAILAPV 600
RNPDQFRTLG LGTPAGILLA GPPGCGKTLL AKAVANESGL NFISVKGPEL LNMYVGESER 660
AVRQVFQRAK NSAPCVIFFD EVDALCPRRS DRETGASVRV VNQLLTEMDG LETRQQVFIL 720
AATNRPDIID PAILRPGRLD KTLFVGLPPP ADRVAILKTI TKNGTKPPLD EDVNLETIAN 780
DLRCNCYTGA DLTALVREAS LCALRQEITA QKNGVGAGEL KVSHKHFEDA FKKVKPSISI 840
KDQVMYEALQ RSLSQ 855 
Gene Ontology
 GO:0016235; C:aggresome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA 
SMART
 SM00382; AAA 
PROSITE
 PS00674; AAA 
PRINTS