| Tag | Content |
|---|
| CPLM ID | CPLM-011807 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Polyamine transporter 4 |
Protein Synonyms/Alias | |
Gene Name | TPO4 |
Gene Synonyms/Alias | YOR273C; O5440 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 23 | TNIQQVPKALDKNVT | ubiquitination | [1] | | 50 | GSITEDEKRSEPNAD | ubiquitination | [1] | | 596 | TDPSTREKPGERLSL | ubiquitination | [1] | | 639 | NSLYSAIKDNEDGYS | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Recognizes spermidine, spermine and the antimalarial drug quinidine, but not quinine, chloroquine and mefloquine. |
Sequence Annotation | MOD_RES 589 589 Phosphothreonine.
MOD_RES 606 606 Phosphothreonine.
MOD_RES 608 608 Phosphothreonine.
MOD_RES 633 633 Phosphoserine.
MOD_RES 646 646 Phosphoserine. |
Keyword | Antiport; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 659 AA |
Protein Sequence | MPSSLTKTES NSDPRTNIQQ VPKALDKNVT NSGNLDSTSS STGSITEDEK RSEPNADSNN 60
MTGGEPIDPR DLDWDGPDDP DNPHNWSSLK KWYTTMTSAF LCLVVTMGSS LYVSSVPELV 120
ERYHVSQTLA LAGLTFYLLG LSTVIGAPLS EVFGRKPVYL FSLPVSMLFT MGVGLSNGHM 180
RIILPLRFLS GVFASPALSV GSGTILDIFD VDQVSVAMTY FVLSPFLGPV LSPIMAGFAT 240
EAKGWRWSEW IQLIAGGLIL PFIALMPETH KGIILRKRAK KRNIALKKFS REAQKEFLKT 300
TVTITILRPL KMLVVEPIVF VFSVYVAFIF AILFGFFEAY AVIYRGVYHM SMGISGLPFI 360
GIGVGLWIGA FFYLYIDRKY LFPKPPAGTQ PLTEKERTSK RTTPYRGARD AETGELLPVV 420
PEKFLIACKF GSVALPIGLF WQAWTARSDV HWMAPVAAGV PFGFGLILIF FSVLMYFSTC 480
YPPLTVASCL AANNLLRYVM SSVFPLFTIQ MYTKMKIKWA STLFALVCVV MIPIPWVFEK 540
WGSKLRHKSQ FGYAAMEKEA ETEGGIDDVN AVDGELNLTR MTTLRTMETD PSTREKPGER 600
LSLRRTHTQP VPASFDREDG QHAQNRNEPI SNSLYSAIKD NEDGYSYTEM ATDASARMV 659 |
Gene Ontology | GO:0000329; C:fungal-type vacuole membrane; IMP:SGD. GO:0016021; C:integral to membrane; ISM:SGD. GO:0005886; C:plasma membrane; IDA:SGD. GO:0015297; F:antiporter activity; IEA:UniProtKB-KW. GO:0015606; F:spermidine transmembrane transporter activity; IMP:SGD. GO:0000297; F:spermine transmembrane transporter activity; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |