UniProt Accession

 K1C17_RAT; Q6IFU8 

Genbank Protein ID

 AABR03073469; BC100058; BK004050 

Genbank Nucleotide ID

 AAI00059.1; DAA04484.1 

Protein Name

 Keratin, type I cytoskeletal 17 

Protein Synonyms/Alias

 Cytokeratin-17; CK-17; Keratin-17; K17; Type I keratin Ka17 

Gene Name

 Krt17 

Gene Synonyms/Alias

 Ka17 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
122	KIRDWYQKQAPGPAR	acetylation	[1]
142	YQTIEDLKNKILVAT	acetylation	[1]
212	EMQIENLKEELAYLK	acetylation	[1]
297	SELVQSGKSEISELR	acetylation	[1]
399	DAHLTQYKPKEPVTT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation (By similarity). 

Sequence Annotation

 REGION 1 83 Head.
 REGION 84 392 Rod.
 REGION 84 120 Coil 1A.
 REGION 121 138 Linker 1.
 REGION 139 230 Coil 1B.
 REGION 231 250 Linker 12.
 REGION 251 392 Coil 2.
 REGION 393 433 Tail.
 MOD_RES 13 13 Phosphoserine (By similarity).
 MOD_RES 32 32 Phosphoserine (By similarity).
 MOD_RES 39 39 Phosphoserine (By similarity).
 MOD_RES 319 319 Phosphoserine (By similarity).  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Intermediate filament; Keratin; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 433 AA 

Protein Sequence

Gene Ontology

 GO:0071944; C:cell periphery; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0045095; C:keratin filament; TAS:RGD.
 GO:0032395; F:MHC class II receptor activity; IEA:Compara.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:RGD.
 GO:0045109; P:intermediate filament organization; IEA:Compara.
 GO:0045103; P:intermediate filament-based process; TAS:RGD.
 GO:0031424; P:keratinization; IEA:Compara.
 GO:0002009; P:morphogenesis of an epithelium; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0051798; P:positive regulation of hair follicle development; IEA:Compara.
 GO:0045727; P:positive regulation of translation; IEA:Compara. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR002957; Keratin_I.
 IPR009053; Prefoldin. 

Pfam

 PF00038; Filament 

SMART

  

PROSITE

 PS00226; IF 

PRINTS

 PR01248; TYPE1KERATIN.