| Tag | Content |
|---|
| CPLM ID | CPLM-007572 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 2,4-dienoyl-CoA reductase [NADPH] |
Protein Synonyms/Alias | 2,4-dienoyl coenzyme A reductase |
Gene Name | fadH |
Gene Synonyms/Alias | ygjL; b3081; JW3052 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 365 | PRACHETKMPILPAV | acetylation | [1] | | 567 | MLQRKASKPGQGLGK | acetylation | [1, 2] | | 574 | KPGQGLGKTTGWIHR | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] [2] The diversity of lysine-acetylated proteins in Escherichia coli. Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG. J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [ PMID: 18852508] |
Functional Description | Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA. |
Sequence Annotation | METAL 335 335 Iron-sulfur (4Fe-4S) (By similarity).
METAL 338 338 Iron-sulfur (4Fe-4S) (By similarity).
METAL 342 342 Iron-sulfur (4Fe-4S) (By similarity).
METAL 354 354 Iron-sulfur (4Fe-4S) (By similarity). |
Keyword | 3D-structure; 4Fe-4S; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 672 AA |
Protein Sequence | MSYPSLFAPL DLGFTTLKNR VLMGSMHTGL EEYPDGAERL AAFYAERARH GVALIVSGGI 60
APDLTGVGME GGAMLNDASQ IPHHRTITEA VHQEGGKIAL QILHTGRYSY QPHLVAPSAL 120
QAPINRFVPH ELSHEEILQL IDNFARCAQL AREAGYDGVE VMGSEGYLIN EFLTLRTNQR 180
SDQWGGDYRN RMRFAVEVVR AVRERVGNDF IIIYRLSMLD LVEDGGTFAE TVELAQAIEA 240
AGATIINTGI GWHEARIPTI ATPVPRGAFS WVTRKLKGHV SLPLVTTNRI NDPQVADDIL 300
SRGDADMVSM ARPFLADAEL LSKAQSGRAD EINTCIGCNQ ACLDQIFVGK VTSCLVNPRA 360
CHETKMPILP AVQKKNLAVV GAGPAGLAFA INAAARGHQV TLFDAHSEIG GQFNIAKQIP 420
GKEEFYETLR YYRRMIEVTG VTLKLNHTVT ADQLQAFDET ILASGIVPRT PPIDGIDHPK 480
VLSYLDVLRD KAPVGNKVAI IGCGGIGFDT AMYLSQPGES TSQNIAGFCN EWGIDSSLQQ 540
AGGLSPQGMQ IPRSPRQIVM LQRKASKPGQ GLGKTTGWIH RTTLLSRGVK MIPGVSYQKI 600
DDDGLHVVIN GETQVLAVDN VVICAGQEPN RALAQPLIDS GKTVHLIGGC DVAMELDARR 660
AIAQGTRLAL EI 672 |
Gene Ontology | GO:0008670; F:2,4-dienoyl-CoA reductase (NADPH) activity; IEA:EC. GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. GO:0010181; F:FMN binding; IEA:InterPro. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |