CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029577
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine-threonine kinase receptor-associated protein 
Protein Synonyms/Alias
 cDNA, FLJ79540, highly similar to Serine-threonine kinase receptor-associatedprotein 
Gene Name
 STRAP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
10LAHKHIVKTVDFTQDacetylation[1]
10LAHKHIVKTVDFTQDubiquitination[2]
28LLTGGQDKLLRIYDLacetylation[1]
28LLTGGQDKLLRIYDLubiquitination[2, 3, 4]
37LRIYDLNKPEAEPKEubiquitination[2, 3, 5]
43NKPEAEPKEISGHTSacetylation[1]
62ALWCSEDKQILSADDubiquitination[6]
141SASLHPEKEFLVAGGubiquitination[3]
155GEDFKLYKYDYNSGEubiquitination[3, 4, 7]
168GEELESYKGHFGPIHacetylation[5]
168GEELESYKGHFGPIHubiquitination[5, 7]
204LWQTVVGKTYGLWKCubiquitination[2, 4, 7]
223EDSGELAKPKIGFPEubiquitination[2, 5]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [7] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Receptor; Reference proteome; Repeat; Transferase; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 256 AA 
Protein Sequence
MTLAHKHIVK TVDFTQDSNY LLTGGQDKLL RIYDLNKPEA EPKEISGHTS GIKKALWCSE 60
DKQILSADDK TVRLWDHATM TEVKSLNFNM SVSSMEYIPE GEILVITYGR SIAFHSAVSL 120
DPIKSFEAPA TINSASLHPE KEFLVAGGED FKLYKYDYNS GEELESYKGH FGPIHCVRFS 180
PDGELYASGS EDGTLRLWQT VVGKTYGLWK CVLPEEDSGE LAKPKIGFPE TTEEELEEIA 240
SENSDCIFPS APDVKA 256 
Gene Ontology
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS