CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040341
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sterol regulatory element-binding protein 1 
Protein Synonyms/Alias
  
Gene Name
 Srebf1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
196SLLLTAVKTDAGATVubiquitination[1]
249HRLAAGSKALGSAQSubiquitination[1]
317QHSNQKLKQENLTLRubiquitination[1]
403AFEDSQVKAQRLPSHubiquitination[1]
518VHFWRHRKQADLDLAubiquitination[1]
853RAALYSFKAARALLDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1076 AA 
Protein Sequence
XETGDTGPSS PGANSPESFS SASLASSLEA FLGGPKVTPA PLSPPPSAPA ALKMYPSVSP 60
FSPGPGIKEE PVPLTILQPA APQPSPGTLL PPSFPAPPVQ LSPAPVLGYS SLPSGFSGTL 120
PGNTQQPPSS LPLAPAPGVL PTPALHTQVQ SLASQQPLPA SAAPRTNTVT SQVQQVPVVL 180
QPHFIKADSL LLTAVKTDAG ATVKTAGIST LAPGTAVQTL VSGGTILATV PLVVDTDKLP 240
IHRLAAGSKA LGSAQSRGEK RTAHNAIEKR YRSSINDKIV ELKDLVVGTE AKLNKSAVLR 300
KAIDYIRFLQ HSNQKLKQEN LTLRSAHKSK SLKDLVSACG SGGGTDVSME GMKPEVVETL 360
TPPPSDAGSP SQSSPLSFGS RASSSGGSDS EPDSPAFEDS QVKAQRLPSH SRGMLDRSRL 420
ALCVLAFLCL TCNPLASLFG WGILTPSDAT GTHRSSGRSM LEAESRDGSN WTQWLLPPLV 480
WLANGLLVLA CLALLFVYGE PVTRPHSGPA VHFWRHRKQA DLDLARGDFP QAAQQLWLAL 540
QALGRPLPTS NLDLACSLLW NLIRHLLQRL WVGRWLAGQA GGLLRDRGLR KDARASARDA 600
AVVYHKLHQL HAMGKYTGGH LAASNLALSA LNLAECAGDA ISMATLAEIY VAAALRVKTS 660
LPRALHFLTR FFLSSARQAC LAQSGSVPLA MQWLCHPVGH RFFVDGDWAV HGAPPESLYS 720
VAGNPVDPLA QVTRLFREHL LERALNCIAQ PSPGAADGDR EFSDALGYLQ LLNSCSDAAG 780
APACSFSVSS SMAATTGPDP VAKWWASLTA VVIHWLRRDE EAAERLYPLV EHIPQVLQDT 840
ERPLPRAALY SFKAARALLD HRKVESSPAS LAICEKASGY LRDSLASTPT GSSIDKAMQL 900
LLCDLLLVAR TSLWQRQQSP ASVQVAHGTS NGPQASALEL RGFQHDLSSL RRLAQSFRPA 960
MRRVFLHEAT ARLMAGASPA RTHQLLDRSL RRRAGSSGKG GTTAELEPRP TWREHTEALL 1020
LASCYLPPAF LSAPGQRMSM LAEAARTVEK LGDHRLLLDC QQMLLRLGGG TTVTSS 1076 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI.
 GO:0008286; P:insulin receptor signaling pathway; IDA:MGI.
 GO:0046676; P:negative regulation of insulin secretion; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0045542; P:positive regulation of cholesterol biosynthetic process; IMP:MGI.
 GO:0031065; P:positive regulation of histone deacetylation; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0010867; P:positive regulation of triglyceride biosynthetic process; IMP:MGI.
 GO:0019217; P:regulation of fatty acid metabolic process; IMP:MGI.
 GO:0003062; P:regulation of heart rate by chemical signal; IMP:MGI.
 GO:0009749; P:response to glucose stimulus; IMP:MGI. 
Interpro
 IPR011598; bHLH_dom. 
Pfam
 PF00010; HLH 
SMART
 SM00353; HLH 
PROSITE
 PS50888; BHLH 
PRINTS