CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001076
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorting nexin-3 
Protein Synonyms/Alias
 SDP3 protein 
Gene Name
 Snx3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
54TTYEIRVKTNLPIFKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation (By similarity). 
Sequence Annotation
 DOMAIN 27 151 PX.
 BINDING 70 70 Phosphatidylinositol 3-phosphate (By
 BINDING 72 72 Phosphatidylinositol 3-phosphate; via
 BINDING 95 95 Phosphatidylinositol 3-phosphate (By
 BINDING 118 118 Phosphatidylinositol 3-phosphate (By
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 72 72 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Endosome; Lipid-binding; Phosphoprotein; Protein transport; Reference proteome; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 162 AA 
Protein Sequence
MAETVADTRR LITKPQNLND AYGPPSNFLE IDVSNPQTVG VGRGRFTTYE IRVKTNLPIF 60
KLKESTVRRR YSDFEWLRSE LERESKVVVP PLPGKAFLRH VPFRGDDGIF DDNFIEERKQ 120
GLEQFINKVA GHPLAQNERC LHMFLQDEII DKSYTPSKIR HA 162 
Gene Ontology
 GO:0005769; C:early endosome; ISS:UniProtKB.
 GO:0010008; C:endosome membrane; ISS:UniProtKB.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR001683; Phox. 
Pfam
 PF00787; PX 
SMART
 SM00312; PX 
PROSITE
 PS50195; PX 
PRINTS