UniProt Accession

 MAT2B_MOUSE; Q99LB6; Q5NC89; Q76LX2; Q8BVX6; Q8BYT9 

Genbank Protein ID

 AB070267; AK038303; AK075947; AK162087; AL646055; AL646055; AL646055; BC003457 

Genbank Nucleotide ID

 BAD06938.1; BAC29963.1; BAC36076.1; BAE36716.1; CAI25424.1; CAI25422.1; CAI25423.1; AAH03457.1 

Protein Name

 Methionine adenosyltransferase 2 subunit beta 

Protein Synonyms/Alias

 Methionine adenosyltransferase II beta; MAT II beta 

Gene Name

 Mat2b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
209	DKVQFSNKSANMDHW	ubiquitination	[1]
225	QRFPTHVKDVASVCR	acetylation	[2]
299	NAQLDCSKLETLGIG	acetylation	[2]
326	LWPFLIDKRWRQTVF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S- adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S- adenosylmethionine inhibition. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; One-carbon metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 334 AA 

Protein Sequence

Gene Ontology

 GO:0048269; C:methionine adenosyltransferase complex; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0008831; F:dTDP-4-dehydrorhamnose reductase activity; IEA:InterPro.
 GO:0048270; F:methionine adenosyltransferase regulator activity; ISS:UniProtKB.
 GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
 GO:0006556; P:S-adenosylmethionine biosynthetic process; ISS:UniProtKB. 

Interpro

 IPR005913; dTDP_dehydrorham_reduct.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF04321; RmlD_sub_bind 

SMART

  

PROSITE

  

PRINTS