CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028211
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 eIF5B, isoform B 
Protein Synonyms/Alias
 eIF5B, isoform C; eIF5B, isoform F 
Gene Name
 eIF5B 
Gene Synonyms/Alias
 CG10840; Dmel_CG10840 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
139KKAKRKGKDDDDEDLacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1144 AA 
Protein Sequence
MVKAKKGKKE ILTKVEGGSS VDEISDVDSD QLSLNNKQNH ALKGNQAGDD DVKAVTKGVK 60
KLNVKGKGKA GKNDDSDEEE VVPAKGKASK KSAFELLMDD DEQDEPAAQE SQSEKEEKVV 120
VSKPQKNEKK GKKAKRKGKD DDDEDLDKVL AELQAEYAGE AAPAATTVVS PEELADEFSK 180
KKKNKKQAKQ AAVAENAGED EASDDEEGGS TVKSAAQKKK EKKERQKREA ALAKQKAATE 240
PKPKPVEKPA PEPEPVATEE VQPAAEEEEE KSSKNKKKGK KDKKAEPEEE KKDAKKKGMS 300
ASMVAAMQEQ LRKRKEEEER LEREEAERIR LEDEREEARL EAVRLEAERK EKKKQREAER 360
KARLKAEGKL LTKKQKEDRA RAQALLESLK AQGLEIPDPN DKRPTRPGTR IRPNKKKGPK 420
EEAAEEEAKA AEAEAQSAAA AAAAAAAEKA EEERVKESWD ATDSEAEPEP EEETSQATNN 480
GKTEAAEEEN EDTDDDEDDD DDEDDSDDSD GDSDDSREVS VLANDPESRR LRAEARILKR 540
QAEAEKKRST DELRAGVVCV LGHVDTGKTK ILDKLRRTHV QDSEAGGITQ QIGATNVPIE 600
AIKEQTKYVK AAAGFEHRLP GLLIIDTPGH ESFSNLRNRG SSLCDIAILV VDIMHGLEPQ 660
TIESIQLLKK KKCPFIVALN KIDRLYDWKQ LARRDVRDVL KEQQSNTQLE FQQRTKDVIL 720
QFAEQGLNAA LFYENTDPKT YISLVPTSAI SGEGMGNLLF MIADFCQNML AKRLMYSEEL 780
QATVLEVKAL PGLGTTIDAI LINGKLREGQ TMVVAGTDGP IVTQIRSLLM PQPMKELRVK 840
NAYVEYKEVK AAQGVKIAAK DLEKAIAGIN LLIAHKPDEV EICTEEVARE LKSALSHIKL 900
AQTGVHVQAS TLGSLEALLE FLRTSKIPYS AIRIGPVVKR DVMKASTMLE HEAQYATILA 960
FDVKIEREAQ EMADSLGVKI FQADIIYHLF DKFTAYREEL KQKKREEFRS VAVFPCKLRI 1020
LPQFVFNSRD PIVMGVMVEN GIVKVGTPIC VPSKEFVDIG IVTSIESNHK QIEFARKGQE 1080
ICVKIDPIPG ESPKMFGRHF EADDMLISKI SRQSIDACKD YFRDDLIKAD WALMVELKKL 1140
FEIL 1144 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:FlyBase.
 GO:0017151; F:DEAD/H-box RNA helicase binding; TAS:FlyBase.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; ISS:FlyBase.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR015760; TIF_IF2.
 IPR023115; TIF_IF2_dom3.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2
 PF11987; IF-2 
SMART
  
PROSITE
  
PRINTS
 PR00315; ELONGATNFCT.