CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005415
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lactaldehyde dehydrogenase 
Protein Synonyms/Alias
 Aldehyde dehydrogenase A; Glycolaldehyde dehydrogenase 
Gene Name
 aldA 
Gene Synonyms/Alias
 ald; b1415; JW1412 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
48GQAEDARKAIDAAERacetylation[1, 2]
190NNAIAFAKIVDEIGLacetylation[2]
243KIMATAAKNITKVCLacetylation[1]
295AERVYVQKGIYDQFVacetylation[2]
340ALERVEQKVARAVEEacetylation[1]
356ARVAFGGKAVEGKGYacetylation[2]
361GGKAVEGKGYYYPPTacetylation[1, 2]
Reference
 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Acts on lactaldehyde as well as other aldehydes. 
Sequence Annotation
 NP_BIND 207 213 NAD (By similarity).
 ACT_SITE 251 251 By similarity.
 ACT_SITE 285 285 By similarity.  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 479 AA 
Protein Sequence
MSVPVQHPMY IDGQFVTWRG DAWIDVVNPA TEAVISRIPD GQAEDARKAI DAAERAQPEW 60
EALPAIERAS WLRKISAGIR ERASEISALI VEEGGKIQQL AEVEVAFTAD YIDYMAEWAR 120
RYEGEIIQSD RPGENILLFK RALGVTTGIL PWNFPFFLIA RKMAPALLTG NTIVIKPSEF 180
TPNNAIAFAK IVDEIGLPRG VFNLVLGRGE TVGQELAGNP KVAMVSMTGS VSAGEKIMAT 240
AAKNITKVCL ELGGKAPAIV MDDADLELAV KAIVDSRVIN SGQVCNCAER VYVQKGIYDQ 300
FVNRLGEAMQ AVQFGNPAER NDIAMGPLIN AAALERVEQK VARAVEEGAR VAFGGKAVEG 360
KGYYYPPTLL LDVRQEMSIM HEETFGPVLP VVAFDTLEDA ISMANDSDYG LTSSIYTQNL 420
NVAMKAIKGL KFGETYINRE NFEAMQGFHA GWRKSGIGGA DGKHGLHEYL QTQVVYLQS 479 
Gene Ontology
 GO:0050569; F:glycolaldehyde dehydrogenase activity; IDA:EcoCyc.
 GO:0008911; F:lactaldehyde dehydrogenase activity; IDA:EcoCyc.
 GO:0004777; F:succinate-semialdehyde dehydrogenase (NAD+) activity; ISS:EcoCyc.
 GO:0019571; P:D-arabinose catabolic process; NAS:EcoCyc.
 GO:0042355; P:L-fucose catabolic process; IEP:EcoCyc.
 GO:0019301; P:rhamnose catabolic process; IMP:EcoCyc. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS