UniProt Accession

 TNNC1_MOUSE; P19123 

Genbank Protein ID

 J04971; M29793; BC061172 

Genbank Nucleotide ID

 AAA37492.1; AAA37493.1; AAH61172.1 

Protein Name

 Troponin C, slow skeletal and cardiac muscles 

Protein Synonyms/Alias

 TN-C 

Gene Name

 Tnnc1 

Gene Synonyms/Alias

 Tncc 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MDDIYKAAVEQLT	ubiquitination	[1]
17	EQLTEEQKNEFKAAF	ubiquitination	[1]
43	ISTKELGKVMRMLGQ	ubiquitination	[1]
90	RCMKDDSKGKSEEEL	ubiquitination	[1]
92	MKDDSKGKSEEELSD	ubiquitination	[1]
106	DLFRMFDKNADGYID	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. 

Sequence Annotation

 DOMAIN 16 51 EF-hand 1.
 DOMAIN 52 87 EF-hand 2.
 DOMAIN 92 127 EF-hand 3.
 DOMAIN 128 161 EF-hand 4.
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Calcium; Complete proteome; Metal-binding; Muscle protein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0005861; C:troponin complex; IEA:Compara.
 GO:0051015; F:actin filament binding; IDA:BHF-UCL.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0043462; P:regulation of ATPase activity; IDA:BHF-UCL.
 GO:0032972; P:regulation of muscle filament sliding speed; IMP:BHF-UCL.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001125; Recoverin. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS

 PR00450; RECOVERIN.