CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018367
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BRI3-binding protein 
Protein Synonyms/Alias
 I3-binding protein; Cervical cancer 1 proto-oncogene-binding protein KG19; HCCRBP-1 
Gene Name
 BRI3BP 
Gene Synonyms/Alias
 KG19 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
71DNVRAAQKFLARLTEubiquitination[1, 2, 3, 4]
229EKLEHLEKQVRLLNIacetylation[4, 5]
229EKLEHLEKQVRLLNIubiquitination[2, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861
Functional Description
 Involved in tumorigenesis and may function by stabilizing p53/TP53. 
Sequence Annotation
 MOD_RES 229 229 N6-acetyllysine.  
Keyword
 Acetylation; Coiled coil; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Proto-oncogene; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 251 AA 
Protein Sequence
MGARASGGPL ARAGLLLLLL LLLLLGLLAP GAQGARGRGG AEKNSYRRTV NTFSQSVSSL 60
FGEDNVRAAQ KFLARLTERF VLGVDMFVET LWKVWTELLD VLGLDVSNLS QYFSPASVSS 120
SPARALLLVG VVLLAYWFLS LTLGFTFSVL HVVFGRFFWI VRVVLFSMSC VYILHKYEGE 180
PENAVLPLCF VVAVYFMTGP MGFYWRSSPS GPSNPSNPSV EEKLEHLEKQ VRLLNIRLNR 240
VLESLDRSKD K 251 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS