UniProt Accession

 C9J586_HUMAN; C9J586 

Genbank Protein ID

 AC097358; AC099327; AC099559; AC099781 

Genbank Nucleotide ID

  

Protein Name

 Rho guanine nucleotide exchange factor 3 

Protein Synonyms/Alias

  

Gene Name

 ARHGEF3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
249	LESPFSRKLDLWNFL	ubiquitination	[1, 2]
265	IPRSRLVKYPLLLRE	ubiquitination	[2]
342	LCCHGELKNNRGVKL	ubiquitination	[2]
382	YRQPIPVKDLLLEDL	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 416 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 

Interpro

 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR011993; PH_like_dom.
 IPR015721; RhoGEF-like. 

Pfam

 PF00621; RhoGEF 

SMART

 SM00325; RhoGEF 

PROSITE

 PS00741; DH_1
 PS50010; DH_2 

PRINTS