CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025495
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase 
Protein Synonyms/Alias
 UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase 
Gene Name
 Gne 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
55CNRADYSKLAPIMFGubiquitination[1]
219AGCPSYDKLLSAKNKubiquitination[1]
226KLLSAKNKDYMSIIRubiquitination[1]
241MWLGDDVKCKDYIVAubiquitination[1]
243LGDDVKCKDYIVALQubiquitination[1]
258HPVTTDIKHSIKMFEubiquitination[1]
290PNIDAGSKEMVRVMRubiquitination[1]
373RDADTQDKILQALHLubiquitination[1]
384ALHLQFGKQYPCSKIubiquitination[1]
390GKQYPCSKIYGDGNAubiquitination[1]
406PRILKFLKSIDLQEPubiquitination[1]
416DLQEPLQKKFCFPPVubiquitination[1]
417LQEPLQKKFCFPPVKubiquitination[1]
471KYTQFNPKTYEERISubiquitination[1]
521GVVLHSTKLIQEWNSubiquitination[1]
649VEGMSVPKDEAVGALubiquitination[1]
663LHLIQAAKLGNVKAQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Isomerase; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 753 AA 
Protein Sequence
METHAHLHRE QSYAGPHELY FKKLSSKKKQ VMEKNGNNRK LRVCVATCNR ADYSKLAPIM 60
FGIKTEPAFF ELDVVVLGSH LIDDYGNTYR MIEQDDFDIN TRLHTIVRGE DEAAMVESVG 120
LALVKLPDVL NRLKPDIMIV HGDRFDALAL ATSAALMNIR ILHIEGGEVS GTIDDSIRHA 180
ITKLAHYHVC CTRSAEQHLI SMCEDHDRIL LAGCPSYDKL LSAKNKDYMS IIRMWLGDDV 240
KCKDYIVALQ HPVTTDIKHS IKMFELTLDA LISFNKRTLV LFPNIDAGSK EMVRVMRKKG 300
IEHHPNFRAV KHVPFDQFIQ LVAHAGCMIG NSSCGVREVG AFGTPVINLG TRQIGRETGE 360
NVLHVRDADT QDKILQALHL QFGKQYPCSK IYGDGNAVPR ILKFLKSIDL QEPLQKKFCF 420
PPVKENISQD IDHILETLSA LAVDLGGTNL RVAIVSMKGE IVKKYTQFNP KTYEERISLI 480
LQMCVEAAAE AVKLNCRILG VGISTGGRVN PQEGVVLHST KLIQEWNSVD LRTPLSDTLH 540
LPVWVDNDGN CAAMAERKFG QGKGQENFVT LITGTGIGGG IIHQHELIHG SSFCAAELGH 600
LVVSLDGPDC SCGSHGCIEA YASGMALQRE AKKLHDEDLL LVEGMSVPKD EAVGALHLIQ 660
AAKLGNVKAQ SILRTAGTAL GLGVVNILHT MNPSLVILSG VLASHYIHIV KDVIRQQALS 720
SVQDVDVVVS DLVDPALLGA ASMVLDYTTR RIH 753 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003824; F:catalytic activity; ISS:MGI.
 GO:0009384; F:N-acylmannosamine kinase activity; IEA:InterPro.
 GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:EC.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
 GO:0046380; P:N-acetylneuraminate biosynthetic process; IEA:InterPro.
 GO:0006054; P:N-acetylneuraminate metabolic process; TAS:MGI.
 GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IEA:InterPro. 
Interpro
 IPR001312; Hexokinase.
 IPR000600; ROK.
 IPR020004; UDP-GlcNAc_Epase.
 IPR003331; UDP_GlcNAc_Epimerase_2. 
Pfam
 PF02350; Epimerase_2
 PF00480; ROK 
SMART
  
PROSITE
  
PRINTS
 PR00475; HEXOKINASE.