UniProt Accession

 ADRO_RAT; P56522 

Genbank Protein ID

 D63761; BC088844 

Genbank Nucleotide ID

 BAA23759.1; AAH88844.1 

Protein Name

 NADPH:adrenodoxin oxidoreductase, mitochondrial 

Protein Synonyms/Alias

 AR; Adrenodoxin reductase; Ferredoxin--NADP(+) reductase; Ferredoxin reductase 

Gene Name

 Fdxr 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
207	TPPEHLEKTDITEVA	acetylation	[1]
242	LQVAFTIKELREMIQ	acetylation	[1]
379	PSVPFDPKLGIIPNT	acetylation	[1]
429	QVLLKDLKAGLLPSG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. 

Sequence Annotation

 NP_BIND 187 190 NADP (By similarity).
 NP_BIND 231 232 NADP (By similarity).
 NP_BIND 408 410 FAD (By similarity).
 BINDING 51 51 FAD; via amide nitrogen (By similarity).
 BINDING 72 72 FAD (By similarity).
 BINDING 80 80 FAD; via amide nitrogen (By similarity).
 BINDING 116 116 FAD; via amide nitrogen and carbonyl
 BINDING 243 243 NADP (By similarity).
 BINDING 401 401 FAD; via amide nitrogen (By similarity).
 BINDING 408 408 NADP; via amide nitrogen (By similarity).  

Keyword

 Cholesterol metabolism; Complete proteome; Direct protein sequencing; Electron transport; FAD; Flavoprotein; Lipid metabolism; Mitochondrion; NADP; Oxidoreductase; Reference proteome; Steroid metabolism; Sterol metabolism; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 494 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0070402; F:NADPH binding; IDA:RGD.
 GO:0015039; F:NADPH-adrenodoxin reductase activity; IDA:RGD.
 GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-UniPathway.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0070995; P:NADPH oxidation; IDA:RGD. 

Interpro

 IPR021163; Adrenodoxin_Rdtase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

  

SMART

  

PROSITE

  

PRINTS