UniProt Accession

 B4DJN5_HUMAN; B4DJN5 

Genbank Protein ID

 AL138996; AL355916; AL359220; AK296158; CH471061 

Genbank Nucleotide ID

 BAG58897.1; EAW80800.1 

Protein Name

 Protein kinase C eta type 

Protein Synonyms/Alias

 Protein kinase C, eta, isoform CRA_a; cDNA FLJ57944, highly similar to Protein kinase C eta type (EC 2.7.11.13) 

Gene Name

 PRKCH 

Gene Synonyms/Alias

 hCG_22361 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
73	NINKVDSKIAEQRFG	ubiquitination	[1]
160	GNISPTSKLVSRSTL	ubiquitination	[1, 2, 3]
176	RQGKESSKEGNGIGV	ubiquitination	[1, 3]
202	EFIRVLGKGSFGKVM	ubiquitination	[1, 3]
214	KVMLARVKETGDLYA	ubiquitination	[3]
243	VECTMTEKRILSLAR	ubiquitination	[1, 3]
320	GIIYRDLKLDNVLLD	ubiquitination	[3]
430	ILKSFMTKNPTMRLG	ubiquitination	[3]
454	ILRHPFFKEIDWAQL	ubiquitination	[2, 3]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 522 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004699; F:calcium-independent protein kinase C activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0045618; P:positive regulation of keratinocyte differentiation; IEA:Compara.
 GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Compara.
 GO:0070528; P:protein kinase C signaling cascade; IEA:Compara. 

Interpro

 IPR000961; AGC-kinase_C.
 IPR020454; DAG/PE-bd.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00130; C1_1
 PF00069; Pkinase
 PF00433; Pkinase_C 

SMART

 SM00109; C1
 SM00133; S_TK_X
 SM00220; S_TKc 

PROSITE

 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 

PRINTS

 PR00008; DAGPEDOMAIN.