UniProt Accession

 RRAGA_HUMAN; Q7L523; B2R7L1; O00290; Q15347 

Genbank Protein ID

 X90529; U41654; AL356000; AK313023; CH471071; BC006433; BC009990 

Genbank Nucleotide ID

 CAA62131.1; AAB63255.1; CAH72136.1; BAG35858.1; EAW58653.1; AAH06433.1; AAH09990.1 

Protein Name

 Ras-related GTP-binding protein A 

Protein Synonyms/Alias

 Rag A; RagA; Adenovirus E3 14.7 kDa-interacting protein 1; FIP-1 

Gene Name

 RRAGA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
307	LERVDGPKHSLLMR*	acetylation	[1]

Reference

 [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 

Functional Description

 Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. 

Sequence Annotation

 NP_BIND 14 21 GTP (By similarity).
 NP_BIND 62 66 GTP (By similarity).
 NP_BIND 127 130 GTP (By similarity).  

Keyword

 Apoptosis; Complete proteome; Cytoplasm; GTP-binding; Host-virus interaction; Lysosome; Nucleotide-binding; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 313 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0051219; F:phosphoprotein binding; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0008219; P:cell death; IDA:UniProtKB.
 GO:0034613; P:cellular protein localization; IMP:UniProtKB.
 GO:0071230; P:cellular response to amino acid stimulus; IMP:UniProtKB.
 GO:0045919; P:positive regulation of cytolysis; IDA:UniProtKB.
 GO:0032008; P:positive regulation of TOR signaling cascade; NAS:UniProtKB.
 GO:0019048; P:virus-host interaction; IDA:UniProtKB. 

Interpro

 IPR006762; Gtr1_RagA.
 IPR027417; P-loop_NTPase. 

Pfam

 PF04670; Gtr1_RagA 

SMART

  

PROSITE

  

PRINTS