UniProt Accession

 MTPN_RAT; P62775; P80144; Q58HB3; Q9DCN8 

Genbank Protein ID

 D26179; U21661; AY951952; BC088136 

Genbank Nucleotide ID

 BAA05167.1; AAC52498.1; AAX54865.1; AAH88136.1 

Protein Name

 Myotrophin 

Protein Synonyms/Alias

 Granule cell differentiation protein; Protein V-1 

Gene Name

 Mtpn 

Gene Synonyms/Alias

 Gcdp 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MCDKEFMWALK	acetylation	[1]
11	KEFMWALKNGDLDEV	acetylation	[1]
19	NGDLDEVKDYVAKGE	acetylation	[1]
24	EVKDYVAKGEDVNRT	acetylation	[1]
90	CVKLLLSKGADKTVK	acetylation	[1]
97	KGADKTVKGPDGLTA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. 

Sequence Annotation

 REPEAT 2 30 ANK 1.
 REPEAT 34 66 ANK 2.
 REPEAT 67 99 ANK 3.
 MOD_RES 2 2 N-acetylcysteine.
 MOD_RES 4 4 N6-acetyllysine (By similarity).
 MOD_RES 11 11 N6-acetyllysine (By similarity).
 MOD_RES 24 24 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; ANK repeat; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 118 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:RGD.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0008290; C:F-actin capping protein complex; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0006584; P:catecholamine metabolic process; IEP:RGD.
 GO:0016049; P:cell growth; IEA:Compara.
 GO:0021707; P:cerebellar granule cell differentiation; IEP:RGD.
 GO:0010613; P:positive regulation of cardiac muscle hypertrophy; IMP:UniProtKB.
 GO:0030307; P:positive regulation of cell growth; IDA:UniProtKB.
 GO:0010557; P:positive regulation of macromolecule biosynthetic process; IDA:UniProtKB.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
 GO:0051247; P:positive regulation of protein metabolic process; IDA:UniProtKB.
 GO:2000812; P:regulation of barbed-end actin filament capping; ISS:UniProtKB.
 GO:0043403; P:skeletal muscle tissue regeneration; IEP:RGD.
 GO:0051146; P:striated muscle cell differentiation; IEP:RGD. 

Interpro

 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 

Pfam

 PF12796; Ank_2 

SMART

 SM00248; ANK 

PROSITE

 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 

PRINTS

 PR01415; ANKYRIN.