UniProt Accession

 BCCIP_HUMAN; Q9P287; B3KP45; Q8ND15; Q96GC4; Q9P288 

Genbank Protein ID

 AB040450; AB040451; AY064247; AY064247; AY064248; AY064249; AK055691; AL834458; AL360176; AL360176; AL360176; BC009771 

Genbank Nucleotide ID

 BAA92927.1; BAA92928.1; AAL55436.1; AAL55438.1; AAL55439.1; AAL55440.1; BAG51557.1; CAD39118.1; CAI12091.1; CAI12092.1; CAI12093.1; AAH09771.1 

Protein Name

 BRCA2 and CDKN1A-interacting protein 

Protein Synonyms/Alias

 P21- and CDK-associated protein 1; Protein TOK-1 

Gene Name

 BCCIP 

Gene Synonyms/Alias

 TOK1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
76	NDYDGIKKLLQQLFL	ubiquitination	[1, 2, 3]
159	FCEKNCEKSMVEQLD	ubiquitination	[2]
174	KFLNDTTKPVGLLLS	ubiquitination	[1, 2, 3]
201	PMYQQLQKELAGAHR	ubiquitination	[2]
231	KTFVEAGKNNSKKKP	ubiquitination	[2]
235	EAGKNNSKKKPSNKK	ubiquitination	[2]
243	KKPSNKKKAALMFAN	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). 

Sequence Annotation

 REGION 59 167 Interaction with BRCA2.
 REGION 161 259 Interaction with CDKN1A.
 MOD_RES 42 42 Phosphoserine.
 MOD_RES 115 115 Phosphoserine.  

Keyword

 Alternative splicing; Cell cycle; Complete proteome; DNA damage; DNA repair; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 314 AA 

Protein Sequence

Gene Ontology

 GO:0019908; C:nuclear cyclin-dependent protein kinase holoenzyme complex; IDA:MGI.
 GO:0019207; F:kinase regulator activity; IDA:MGI.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0061101; P:neuroendocrine cell differentiation; IDA:UniProtKB.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:MGI. 

Interpro

 IPR025602; BCP1_family. 

Pfam

 PF13862; BCIP 

SMART

  

PROSITE

  

PRINTS