UniProt Accession

 CDC42_RAT; Q8CFN2; Q6P9Y3; Q71TW5 

Genbank Protein ID

 AF205635; AF491841; BC060535 

Genbank Nucleotide ID

 AAF15538.1; AAN63806.1; AAH60535.1 

Protein Name

 Cell division control protein 42 homolog 

Protein Synonyms/Alias

  

Gene Name

 Cdc42 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
128	DDPSTIEKLAKNKQK	acetylation	[1]
135	KLAKNKQKPITPETA	acetylation	[1]
135	KLAKNKQKPITPETA	ubiquitination	[2]
144	ITPETAEKLARDLKA	acetylation	[1]
144	ITPETAEKLARDLKA	ubiquitination	[2]
150	EKLARDLKAVKYVEC	acetylation	[1]
153	ARDLKAVKYVECSAL	acetylation	[1]
166	ALTQKGLKNVFDEAI	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration (By similarity). 

Sequence Annotation

 NP_BIND 10 17 GTP (By similarity).
 NP_BIND 57 61 GTP (By similarity).
 NP_BIND 115 118 GTP (By similarity).
 MOTIF 32 40 Effector region (Potential).
 MOD_RES 64 64 Phosphotyrosine; by SRC (By similarity).
 MOD_RES 188 188 Cysteine methyl ester (By similarity).
 LIPID 188 188 S-geranylgeranyl cysteine (By  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Differentiation; Direct protein sequencing; GTP-binding; Lipoprotein; Membrane; Methylation; Neurogenesis; Nucleotide-binding; Phosphoprotein; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 191 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030175; C:filopodium; IEA:Compara.
 GO:0000139; C:Golgi membrane; IDA:BHF-UCL.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; ISS:UniProtKB.
 GO:0072686; C:mitotic spindle; ISS:UniProtKB.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0030141; C:secretory granule; IDA:UniProtKB.
 GO:0051233; C:spindle midzone; ISS:UniProtKB.
 GO:0005525; F:GTP binding; TAS:UniProtKB.
 GO:0003924; F:GTPase activity; TAS:RGD.
 GO:0090135; P:actin filament branching; IMP:RGD.
 GO:0051017; P:actin filament bundle assembly; IEA:Compara.
 GO:0034332; P:adherens junction organization; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0003161; P:cardiac conduction system development; IEA:Compara.
 GO:0034613; P:cellular protein localization; IEA:Compara.
 GO:0090136; P:epithelial cell-cell adhesion; IEA:Compara.
 GO:0060684; P:epithelial-mesenchymal cell signaling; IEA:Compara.
 GO:0030010; P:establishment of cell polarity; TAS:RGD.
 GO:0051683; P:establishment of Golgi localization; IMP:BHF-UCL.
 GO:0035088; P:establishment or maintenance of apical/basal cell polarity; IEA:Compara.
 GO:0046847; P:filopodium assembly; IEA:Compara.
 GO:0007030; P:Golgi organization; IMP:BHF-UCL.
 GO:0031069; P:hair follicle morphogenesis; IEA:Compara.
 GO:0060789; P:hair follicle placode formation; IEA:Compara.
 GO:0060047; P:heart contraction; IEA:Compara.
 GO:0031424; P:keratinization; IEA:Compara.
 GO:0003334; P:keratinocyte development; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:0031333; P:negative regulation of protein complex assembly; IEA:Compara.
 GO:0048664; P:neuron fate determination; IEA:Compara.
 GO:0007097; P:nuclear migration; IEA:Compara.
 GO:0072384; P:organelle transport along microtubule; IMP:BHF-UCL.
 GO:0032467; P:positive regulation of cytokinesis; ISS:UniProtKB.
 GO:0045740; P:positive regulation of DNA replication; IMP:RGD.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0071338; P:positive regulation of hair follicle cell proliferation; IEA:Compara.
 GO:0090316; P:positive regulation of intracellular protein transport; IMP:RGD.
 GO:0046330; P:positive regulation of JNK cascade; IDA:RGD.
 GO:0048554; P:positive regulation of metalloenzyme activity; IMP:RGD.
 GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Compara.
 GO:0031274; P:positive regulation of pseudopodium assembly; IEA:Compara.
 GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; ISS:UniProtKB.
 GO:0051835; P:positive regulation of synapse structural plasticity; IMP:RGD.
 GO:0051988; P:regulation of attachment of spindle microtubules to kinetochore; ISS:UniProtKB.
 GO:0017157; P:regulation of exocytosis; TAS:UniProtKB.
 GO:0051489; P:regulation of filopodium assembly; ISS:UniProtKB.
 GO:0007088; P:regulation of mitosis; IEA:Compara.
 GO:0042176; P:regulation of protein catabolic process; IEA:Compara.
 GO:0043497; P:regulation of protein heterodimerization activity; IEA:Compara.
 GO:0045859; P:regulation of protein kinase activity; IEA:Compara.
 GO:0031647; P:regulation of protein stability; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; TAS:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0002040; P:sprouting angiogenesis; IMP:RGD.
 GO:0060661; P:submandibular salivary gland formation; IEP:RGD. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.