UniProt Accession

 ORML3_HUMAN; Q8N138; B3KS83; Q6UY83 

Genbank Protein ID

 AF395708; AF373101; AF373102; AK074811; AY357943; AK075212; AK093063; CH471152; BC017087; BC071833 

Genbank Nucleotide ID

 AAM43507.1; AAN76521.1; AAN76522.1; BAC11223.1; AAQ57273.1; BAC11476.1; BAG52645.1; EAW60617.1; AAH17087.1; AAH71833.1 

Protein Name

 ORM1-like protein 3 

Protein Synonyms/Alias

  

Gene Name

 ORMDL3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
152	VRIFGINKY******	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling. 

Sequence Annotation

  

Keyword

 Alternative splicing; Asthma; Complete proteome; Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 153 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0035339; C:SPOTS complex; IDA:UniProtKB.
 GO:0006672; P:ceramide metabolic process; IMP:UniProtKB. 

Interpro

 IPR007203; ORMDL. 

Pfam

 PF04061; ORMDL 

SMART

  

PROSITE

  

PRINTS