UniProt Accession

 MYL6_HUMAN; P60660; P16475; P24572; P24573; Q12790; Q561V9; Q6IAZ0; Q6IPY5 

Genbank Protein ID

 M22918; M22919; M22919; M22920; M31212; U02629; AB046613; CR457014; BC006781; BC017455; BC071661; BC093066 

Genbank Nucleotide ID

 AAA36347.1; AAA59892.1; AAA59893.1; AAA36348.1; AAA59853.1; AAA20643.1; BAB62402.1; CAG33295.1; AAH06781.2; AAH17455.1; AAH71661.1; AAH93066.1 

Protein Name

 Myosin light polypeptide 6 

Protein Synonyms/Alias

 17 kDa myosin light chain; LC17; Myosin light chain 3; MLC-3; Myosin light chain alkali 3; Myosin light chain A3; Smooth muscle and nonmuscle myosin light chain alkali 6 

Gene Name

 MYL6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
50	PTNAEVLKVLGNPKS	ubiquitination	[1]
56	LKVLGNPKSDEMNVK	ubiquitination	[1]
63	KSDEMNVKVLDFEHF	ubiquitination	[1]
79	PMLQTVAKNKDQGTY	ubiquitination	[1]
81	LQTVAKNKDQGTYED	ubiquitination	[1]
98	EGLRVFDKEGNGTVM	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Regulatory light chain of myosin. Does not bind calcium. 

Sequence Annotation

 DOMAIN 7 42 EF-hand 1.
 DOMAIN 84 119 EF-hand 2.
 DOMAIN 119 151 EF-hand 3.
 MOD_RES 2 2 N-acetylcysteine.
 MOD_RES 81 81 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Motor protein; Muscle protein; Myosin; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 151 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016461; C:unconventional myosin complex; TAS:BHF-UCL.
 GO:0030898; F:actin-dependent ATPase activity; ISS:HGNC.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0003774; F:motor activity; TAS:HGNC.
 GO:0008307; F:structural constituent of muscle; IDA:HGNC.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0030049; P:muscle filament sliding; TAS:HGNC.
 GO:0007519; P:skeletal muscle tissue development; TAS:UniProtKB. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom. 

Pfam

 PF13405; EF_hand_4 

SMART

 SM00054; EFh 

PROSITE

 PS50222; EF_HAND_2 

PRINTS